6378-25-2Relevant academic research and scientific papers
Synthesis method of 2, 4, 5-trichlorobenzenesulfonic acid
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Paragraph 0040-0084, (2021/07/24)
The invention provides a synthesis method of 2, 4, 5-trichlorobenzenesulfonic acid, which comprises the following steps of: respectively adding sulfur trioxide and 1, 2, 4-trichlorobenzene into an organic solvent to obtain a sulfur trioxide solution and a 1, 2, 4-trichlorobenzene solution; respectively adding the sulfur trioxide solution and the 1, 2, 4-trichlorobenzene solution into a micro-channel reactor, carrying out sulfonation reaction, filtering a reaction product, and washing and drying the reaction product to obtain 2, 4, 5-trichlorobenzene sulfonic acid. According to the synthesis method, the micro-channel reactor is used for reaction, the mass transfer and heat transfer efficiency of reactants can be enhanced, the mass transfer and heat transfer effects of the sulfonation reaction in a short time can be achieved through the micron-scale to millimeter-scale reaction channel size, the product can be continuously synthesized in a continuous feeding mode, the amplification effect does not exist, the safety risk problem that in the prior art, sulfur trioxide serving as a sulfonating agent is too active, polysulfonation and oxidation side reactions are prone to occurring, and a lot of heat is released is solved, and the reaction yield is increased.
2,5-dichlorophenylthioglycolic acid derivative and method for its production
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, (2008/06/13)
The present invention is directed to novel 2,5-dichlorophenylthioglycolic acid derivative, a process for their production and a process for producing the desired product 2,5-dichlorophenylthioglycolic acid derived from said novel compounds. 2,5-dichlorophenylthioglycolic acid derivative of the present invention can be obtained by reacting 2,4,5-trichlorobenzensulfonates and thioglycolic acid in the presence of base, and said desired product can be obtained by desulfonating said compound in an aqueous solution of mineral acid. Novel 4-carboxymethylthio-2,5-dichlorobenzenesulfonates of the present invention can be used advantageously as an intermediate for the production of 2,5-dichlorophenylthioglycolic acid. The use of said intermediate makes it possible to obtain the desired product in a decreased process steps with high yield. In addition, it poses no problem of environmental pollution as pointed out with conventional methods because it uses no heavy metals.
