63782-91-2

Basic information

• Product Name: (3RS,4SR)-4-methyl-heptan-3-ol
• CAS NO: 63782-91-2
• Molecular Weight: 130.23
• Mol File: 63782-91-2.mol

Chemical Properties

• CAS DataBase Reference: (3RS,4SR)-4-methyl-heptan-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (3RS,4SR)-4-methyl-heptan-3-ol(63782-91-2)
• EPA Substance Registry System: (3RS,4SR)-4-methyl-heptan-3-ol(63782-91-2)

Safety Data

• Hazardous Substances Data: 63782-91-2(Hazardous Substances Data)

Upstream product

• 76291-88-8 (R)-4-Hydroxy-hex-2-ynoic acid 
• 34405-50-0 4-ethyl-3-methyl-γ-butyrolactone 
• 34405-51-1 trans-β-methyl-γ-ethyl-γ-butyrolactone 
• 6137-11-7 4-methyl-3-heptanone 
• 14979-39-6 4-methyl-3-heptanol 
• 123-15-9 2-methylvaleraldehyde 
• 925-90-6 ethylmagnesium bromide 
• 917-54-4 methyllithium 
• 53229-39-3 (RS)-((RS)-1-methyl-butyl)-oxirane 
• 77075-70-8 (4S,5R)-5-Ethyl-4-methyl-tetrahydro-furan-2-ol 
• 77075-72-0 (R)-4-(Tetrahydro-pyran-2-yloxy)-hex-2-ynoic acid ethyl ester 
• 76695-82-4 (R)-ethyl 4-hydroxyhex-2-ynoate 
• 52945-87-6 (R)-5-Ethyl-4-methyl-5H-furan-2-one 
• 2407-43-4 5-ethyl-5H-furan-2-one 

Downstream Products

• 51532-31-1 (+)-(S)-4-methyl-heptane-3-one 
• 51532-30-0 (S)-(+)-4-methylheptan-3-one 

Relevant articles and documents

PREPARATION DES METHYL-4 HEPTANOLS-3 ERYTHRO ET THREO OPTIQUEMENT PURS.

Optically pure enantiomers of threo and erythro 4-methylheptan-3 ols are synthesized from optically active butenolides 2 and 3 obtained via an asymmetric synthesis of propargylic carbinols.

Synthesis of β-Methyl Alcohols: Influence of Alkyl Chain Length on Diastereoselectivity and New Attractants of Rhynchophorus ferrugineus

The diastereoselectivity of adducts in the addition reaction via the Felkin-Anh model is affected significantly by the steric effect of bulky groups. However, the influence of steric alkyl chain length has not been studied for the diastereoselectivity. In this work, we present a new strategy for the racemic synthesis of β-methyl alcohols to obtain various diastereomer ratios using the Felkin-Anh model. The addition of alkyl Grignard reagents to α-methyl aldehydes afforded diastereomer ratios of threo/erythro ≈ 2:1, while the reduction in structurally related ketones using LiAlH4 afforded ratios of threo/erythro ≈ 1:1. The experimental data showed no effect of alkyl chain length on either side on the stereoselectivity of adducts. All synthesized analogues were evaluated for attractiveness to Rhynchophorus ferrugineus weevils in the field. Five novel derivatives, including two alcohols and three ketones, were found to attract weevils in the field trials. Among them, 3-methyldecan-4-one (5b) and 4-methyldecan-5-ol (11a) were found to be the most attractive to the insects.

Enantioselective preparation of the stereoisomers of 4-methylheptan-3-ol using Candida antarctica lipase B

The four stereoisomers of 4-methylheptan-3-ol were prepared through fractional crystallization of a mixture of their racemic 4-methylhept-3-yl 3,5-dinitrobenzoates, followed by hydrolysis of each crystalline racemate and enantioselective, lipase-mediated transesterification of each pair of enantiomeric alcohols liberated, using the Candida antarctica lipase B as catalyst and 5-ethyl octanethioate as the acyl donor. An analytical method of determining the enantiomeric composition of mixtures of 4-methyl-heptan-3-ols was developed. The optical purity of the separated isomers was in the range of 29-97%.