63786-66-3Relevant academic research and scientific papers
On the reactivity of benzo[a]phenazine-5,6-dione 7-oxides with methanolic alkali and pyrrolidine
Gornostaev, Leonid M.,Rukovets, Tatyana A.,Arnold, Elena V.,Lavrikova, Tatyana I.,Khalyavina, Juliya G.,Kryukovskaya, Irina S.
, p. 166 - 169 (2015)
[MediaObject not available: see fulltext.]When treated with methanolic alkali, benzo[a]phenazine-5,6-dione 7-oxides convert into 11H-indeno[1,2-b]quinoxalin-11-ones, whereas 11-hydroxy-11-(pyrrolidine-1-carbonyl)-11H-indeno[1,2-b]quinoxaline 10-oxides form upon treatment with pyrrolidine.
DNA interaction, anticancer, antibacterial, ROS and lipid peroxidation studies of quinoxaline based organometallic Re(I) carbonyls
Varma, Reena R.,Pandya, Juhee G.,Vaidya, Foram U.,Pathak, Chandramani,Dabhi, Ravi A.,Dhaduk, Milan P.,Bhatt, Bhupesh S.,Patel, Mohan N.
, (2021/05/19)
Hetero mononuclear rhenium(I) complexes (I-V) using ligands (L1-L5) [L1-L5 = 11-((2-chlorobenzylidene)hydrazono)-11H-indeno[1,2-b]quinoxaline (L1), 8-methyl-11-((4-methyl-benzylidene)hydrazono)-11H-indeno[1,2-b]quinoxaline (L2), 11-((4-bromobenzylidene) hydrazono)-8-nitro-11H-indeno[1,2-b]quinoxaline (L3), 11-((4-bromobenzylidene) hydrazono)-8-chloro-11H-indeno[1,2-b]quinoxaline (L4), 8-bromo-11-((4-fluorobenzylidene) hydrazono)-11H-indeno[1,2-b]quinoxaline (L5)] were synthesized and characterized by spectroscopic method. All the synthesized compounds have biological importance. DNA interaction studies gave information about the modes of binding and the nucleolytic efficiency of compounds. The binding of the rhenium complexes to Herring sperm DNA (HS DNA) was monitored by UV–visible spectroscopy, viscosity measurements, and molecular docking studies; groove binding was suggested as the most possible mode. The DNA-complexes binding strength was measured in terms of intrinsic binding constants. In vivo and In vitro cytotoxicity against the eukaryotic and prokaryotic cells gave the toxic nature of the synthesized compounds. An antimicrobial study was carried out by estimating MIC (Minimum Inhibitory Concentration) against two Gram-positive (S. aureus, B. subtilis) and three Gram-negative (S. marcescens, P. aeruginosa, E. coli) bacteria. All synthesized complexes are biologically more active than the corresponding ligands. Complexes were having higher MDA and H2O2 production than ligands.
Synthesis of spirohydantoins and schiff bases of indenoquinoxalinones and indenopyridopyrazinones
Song,Bae,Shin,Jung,Cho
, p. 1925 - 1930 (2020/09/02)
The main structure of many compounds containing spirohydantoin and Schiff bases of indenoquinoxalines and indenopyridopyrazinones expose valuable pharmacological properties. Herein, an effective synthesis and stereochemistry of indenoquinoxalinones (2a, 2
