638-43-7 Usage
General Description
[(2-aminoethyl)disulfanyl]acetic acid, also known as tiopronin, is a pharmaceutical compound used in the treatment of kidney stones and in the management of cystinuria, a rare genetic disorder causing the formation of cystine stones in the kidneys and bladder. As a thiol compound, tiopronin works by binding to cystine molecules, preventing them from aggregating and forming stones. It is a derivative of cysteine and is structurally similar to the amino acid, exhibiting antioxidant properties. Moreover, it has been found to be effective in enhancing the excretion of heavy metals such as mercury and lead from the body, making it useful in cases of heavy metal poisoning or toxicity. Overall, tiopronin is a versatile chemical with important medical applications in the treatment and management of various conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 638-43-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,3 and 8 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 638-43:
(5*6)+(4*3)+(3*8)+(2*4)+(1*3)=77
77 % 10 = 7
So 638-43-7 is a valid CAS Registry Number.
638-43-7Relevant articles and documents
A kinetic approach to characterize the electrostatic environments of thiol groups in proteins
Zhang, Hao,Le, Min,Means, Gary E.
, p. 356 - 364 (2007/10/03)
In this study, we synthesized a zwitterionic DTNB derivative, 5-(2- aminoethyl)-dithio-2-nitrobenzoate (ADNB), and characterized its reactions with several cationic, anionic, and neutral thiols. Reactions with ADNB, unlike those with DTNB, are relatively insensitive to electrostatic environments and ionic strengths. At relatively low ionic strength, rate ratios, k(ADNB)/k(DTNB), varied from 0.22 for reactions with low-molecular- weight cationic thiols to 3.0 for those with low-molecular-weight anionic thiols. A k(ADNB)/k(DTNB) ratio of ~200 for Cys-34 of BSA appears to reflect a very anionic environment. k(ADNB)/k(DTNB) ratios of ~6 and ~1, respectively, for canine and equine serum albumins, which have Glu-82 → Asp and Glu-82 → Ala substitutions suggest Glu-82 is the most important anionic residues affecting the reactivity of Cys-34 in BSA. k(ADNB)/k(DTNB) ratios appear to be useful for characterizing electrostatic environments of thiol groups in proteins.
