6380-63-8Relevant academic research and scientific papers
Alpha-cyanoethylphthalate and preparation thereof
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, (2008/06/13)
This invention relates to a method for preparation of a stereo isomer mixture of crystalline alpha-cyanoethylphthalate wherein the stereo isomer mixture is separated from the reaction mixture by precipitation. More particularly, the stereo isomer mixture is initially formed by reacting lactonitrile and a phthalic acid halide in an organic liquid solution at ambient conditions and the stereo isomer mixture precipitated therefrom by adding an organic precipitant liquid to the reaction mixture. By-products and side-reaction products can be washed from the reaction mixture prior to precipitation of the stereo isomer mixture to provide an alpha-cyanoethylphthalate product having greater purity than conventionally obtained. Additionally, the present alpha-cyanoethylphthalate composition can be characterized as a mixture of the meso and dl isomers wherein one isomer has a predominant weight ratio in the mixture.
