63812-15-7

Basic information

• Product Name: 2-FLUOROISOBUTYRIC ACID
• Synonyms: 2-FLUOROISOBUTRYIC ACID;2-FLUOROISOBUTYRIC ACID;2-FLUORO-2-METHYLPROPIONIC ACID;2-Fluoroisobutanoic acid;2-Fluoro-2-methylpropanoic acid;Propanoic acid, 2-fluoro-2-methyl-
• CAS NO: 63812-15-7
• Molecular Formula: C₄H₇FO₂
• Molecular Weight: 106.1
• Mol File: 63812-15-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 57 °C
• Flash Point: 57-58°C/10mm
• Appearance: /
• Density: 1.120
• Vapor Pressure: 1.07mmHg at 25°C
• Refractive Index: 1.3850
• PKA: 2.68±0.10(Predicted)
• Water Solubility: Soluble in water.
• CAS DataBase Reference: 2-FLUOROISOBUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUOROISOBUTYRIC ACID(63812-15-7)
• EPA Substance Registry System: 2-FLUOROISOBUTYRIC ACID(63812-15-7)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-23/24/25
• Safety Statements: 26-36/37/39-45
• RIDADR: 3265
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 63812-15-7(Hazardous Substances Data)

Usage

Chemical Properties

Liquid

Uses

2-Fluoroisobutyric acid chloride was synthesized from 2-fluoroisobutyric acid and oxalyl chloride. Reactant in the synthesis of 2-Fluoro-Acids, Esters, and amides From a-Dicyanoepoxides.

InChI:InChI=1/C4H7FO2/c1-4(2,5)3(6)7/h1-2H3,(H,6,7)

Upstream product

• 55816-69-8 ethyl 2-fluoro-isobutyrate 
• 57-09-0 cetyltrimethylammonim bromide 
• 1026976-92-0 3-Fluoro-3-methyl-2-oxo-butyronitrile 

Relevant articles and documents

Silver-catalyzed monofluoroalkylation of heteroarenes with α-fluorocarboxylic acids: an insight into the solvent effect

A mild and efficient method for direct C-H monofluoroalkylation of heteroarenes with easily accessible and inexpensive α-fluorocarboxylic acids has been developed. This silver-catalyzed reaction affords mono- and bis-monofluoroalkylated heteroarenes in good yields under mild conditions, and the solvent effect on the monofluoroalkylation reaction is discussed in detail.

Synthesis of 2-fluoro- acids, esters, and amides from α-dicyanoepoxides

The opening of α-dicyanoepoxides by pyridine polyhydrofluoride yields polymerisable 2-fluorocyanoformyls which may be kept intact when diluated in dichloromethane or ether. These intermediates react with nucleophiles such as water, methanol or amines to give respectively 2-fluoroacids, esters or amides.