638160-01-7

Basic information

• Product Name: 5-[4-(TrifluoroMethoxy)phenyl]furan-2-carboxylic Acid
• Synonyms: 5-[4-(TrifluoroMethoxy)phenyl]furan-2-carboxylic Acid;5-[4-(trifluoromethoxy)phenyl]-2-Furancarboxylic acid
• CAS NO: 638160-01-7
• Molecular Formula: C₁₂H₇F₃O₄
• Molecular Weight: 272.1767896
• Mol File: 638160-01-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 355.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.429±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.97±0.10(Predicted)
• CAS DataBase Reference: 5-[4-(TrifluoroMethoxy)phenyl]furan-2-carboxylic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[4-(TrifluoroMethoxy)phenyl]furan-2-carboxylic Acid(638160-01-7)
• EPA Substance Registry System: 5-[4-(TrifluoroMethoxy)phenyl]furan-2-carboxylic Acid(638160-01-7)

Safety Data

• Hazardous Substances Data: 638160-01-7(Hazardous Substances Data)

Usage

Description

5-[4-(TrifluoroMethoxy)phenyl]furan-2-carboxylic Acid is a chemical compound characterized by a molecular formula of C13H7F3O4. It features a furan ring with a carboxylic acid group and a phenyl group that is substituted with a trifluoromethoxy (OCF3) group. 5-[4-(TrifluoroMethoxy)phenyl]furan-2-carboxylic Acid is recognized for its potential in organic synthesis and pharmaceutical research, making it a valuable building block for developing novel molecules with possible biological activity or therapeutic applications.

Uses

Used in Organic Synthesis:
5-[4-(TrifluoroMethoxy)phenyl]furan-2-carboxylic Acid is used as a key intermediate in organic synthesis for the creation of complex organic molecules. Its unique structure allows for the development of new compounds with diverse applications across various industries.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-[4-(TrifluoroMethoxy)phenyl]furan-2-carboxylic Acid is utilized as a starting material for the development of new drugs. Its properties make it a promising candidate for the synthesis of molecules with potential therapeutic uses.
Used in Medicinal Chemistry:
5-[4-(TrifluoroMethoxy)phenyl]furan-2-carboxylic Acid is employed as a building block in medicinal chemistry to design and synthesize bioactive molecules. Its structure contributes to the discovery of new compounds with potential applications in treating various diseases.
Used in Drug Discovery:
In the field of drug discovery, 5-[4-(TrifluoroMethoxy)phenyl]furan-2-carboxylic Acid is used to explore its potential as a precursor for the development of innovative pharmaceutical agents. Its unique properties make it an attractive candidate for further research and development.
Overall, 5-[4-(TrifluoroMethoxy)phenyl]furan-2-carboxylic Acid is a versatile chemical compound with applications in various scientific fields, particularly in the development of new drugs and organic molecules with potential therapeutic uses.

Upstream product

• 2527-99-3 methyl 5-bromo-2-furoate 
• 585-70-6 5-bromo-furan-2-carboxylic acid 
• 773138-91-3 C₁₄H₁₁F₃O₄ 
• 139301-27-2 4-trifluoromethoxyphenylboronic acid 

Downstream Products

• 1007197-72-9 C₁₉H₁₄F₃NO₃ 
• 1258268-74-4 C₂₀H₁₆F₃NO₃ 

Relevant articles and documents

Hedgehog signal pathway inhibitor

The invention provides a Hedgehog signal pathway inhibitor as well as stereoisomers, tautomers, hydrates, solvates or pharmaceutically acceptable salts thereof, and the structural formula of the inhibitor is as shown in a formula (I). The invention further provides a preparation method and application of a compound. The compound provided by the invention is novel in structure; a signal transduction pathway adjusted by Hedgehog protein, Ptch, Gli and/or Smo can be adjusted through the compound of the formula I.

Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain

Nav1.8 (also known as PN3) is a tetrodotoxin-resistant (TTx-r) voltage-gated sodium channel (VGSC) that is highly expressed on small diameter sensory neurons and has been implicated in the pathophysiology of inflammatory and neuropathic pain. Recent studies using an NavL8 antisense oligonucleotide in an animal model of chronic pain indicated that selective blockade of Nav1.8 was analgesic and could provide effective analgesia with a reduction in the adverse events associated with nonselective VGSC blocking therapeutic agents. Herein, we describe the preparation and characterization of a series of 5-substituted 2-furfuramides, which are potent, voltage-dependent blockers (IC50 v1.8 channel. Selected derivatives, such as 7 and 27, also blocked TTx-r sodium currents in rat dorsal root ganglia (DRG) neurons with comparable potency and displayed > 100-fold selectivity versus human sodium (Na v1.2, Nav1.5, Nav1.7) and human ether-a-go-go (hERG) channels. Following systemic administration, compounds 7 and 27 dose-dependently reduced neuropathic and inflammatory pain in experimental rodent models.