638166-53-7Relevant academic research and scientific papers
Platinum-catalyzed enantioselective tandem alkylation/arylation of primary phosphines. Asymmetric synthesis of p-stereogenic 1-phosphaacenaphthenes
Anderson, Brian J.,Guino-o, Marites A.,Glueck, David S.,Golen, James A.,Dipasquale, Antonio G.,Liable-Sands, Louise M.,Rheingold, Arnold L.
supporting information; experimental part, p. 4425 - 4428 (2009/05/11)
(Chemical Equation Presented) Enantioselective tandem alkylation/arylation of primary phosphines with 1-bromo-8-chloromethylnaphthalene catalyzed by Pt(DuPhos) complexes gave P-stereogenic 1-phosphaacenaphthenes (AcePhos) in up to 74% ee. Diastereoselective formation of four P-C bonds in one pot with bis(primary) phosphines gave C2-symmetric diphosphines, including the ophenylene derivative DuAcePhos, for which the rac isomer was formed with high enantioselectivity. These reactions, which appear to proceed via an unusual metal-mediated nucleophilic aromatic substitution pathway, yield a new class of heterocycles with potential applications in asymmetric catalysis.
