638211-24-2Relevant academic research and scientific papers
Stereoselectivity of the Honda-Reformatsky reaction in reactions with ethyl bromodifluoroacetate with α-oxygenated sulfinylimines
Fontenelle, Clement Q.,Conroy, Matthew,Light, Mark,Poisson, Thomas,Pannecoucke, Xavier,Linclau, Bruno
, p. 4186 - 4195 (2014/05/20)
The Reformatsky reaction of ethyl bromodifluoroacetate to α-oxygenated sulfinylimines is described. Using Honda-Reformatsky conditions, the reaction proceeds with double diastereodifferentiation, with the configuration of the sulfinyl group determining th
One-pot microwave-promoted synthesis of nitriles from aldehydes via tert-butanesulfinyl imines
Tanuwidjaja, Jessica,Peltier, Hillary M.,Lewis, Jared C.,Schenkel, Laurie B.,Ellman, Jonathan A.
, p. 3385 - 3389 (2008/09/20)
A facile, one-pot method for the synthesis of nitriles from aldehydes via a microwave-promoted, concerted elimination of tert-butanesulfenic acid from tert-butanesulfinyl-protected imines, is described. The mild reaction conditions exhibit broad functional group compatibility and generate products in good isolated yield (69-87%). This method provides a rapid and mild procedure for the synthesis of various functionalized nitriles. Georg Thieme Verlag Stuttgart.
Stereoselective Synthesis of 1,2-Disubstituted β-Amino Alcohols by Nucleophilic Addition to N-tert-Butanesulfinyl α-Alkoxyaldimines
Evans, Jared W.,Ellman, Jonathan A.
, p. 9948 - 9957 (2007/10/03)
N-tert-Butanesulfinyl α-alkoxyaldimines are readily prepared from protected (S)-lactals without epimerization at the α-stereocenter. Addition of ethyl and phenyl Grignard reagents, as well as the titanium enolate of methyl acetate, to the N-tert-butanesul
