638213-36-2Relevant academic research and scientific papers
Free radical-mediated vinyl amination: A mild, general pyrrolidinyl enamine synthesis
Nugent, Benjamin M.,Williams, Amie L.,Prabhakaran,Johnston, Jeffrey N.
, p. 8877 - 8888 (2007/10/03)
The complete scope of free radical-mediated vinyl amination is described, using 5-exo-trig cyclizations of vinyl radicals to the nitrogen of azomethines. The focus is primarily on N,N-dialkyl enamines since their nucleophilicity renders them the most challenging enamines to synthesize using redox conditions. These studies establish several encouraging precedents for the broader application of this strategy.
