6383-98-8Relevant academic research and scientific papers
Synthesis of 3,5-disubstituted 1,2,4-triazoles containing an amino group
Khromova, N. Yu.,Fedorov,Malekin,Kutkin
, p. 1490 - 1495 (2016/11/29)
3,5-Disubstituted 1,2,4-triazoles containing linear and cyclic amine fragments have been synthesized by thermal cyclization of N′-(1-iminoalkyl) hydrazides prepared by condensation of imido esters with carboxylic acid hydrazides. The initial imido esters have been synthesized by the Pinner reaction, as well as by reaction of nitriles with methanol in the presence of a catalytic amount of sodium methoxide. A procedure has been developed for the synthesis of 5-substituted 3-(3-nitrophenyl)-1,2,4-triazoles which have been converted to 3-aminophenyl derivatives by reduction with hydrazine hydrate over Raney nickel.
