63839-24-7

Basic information

• Product Name: 6-BROMO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE
• Synonyms: 6-BROMO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE;6-BROMO-2,3-DIHYDRO-1H-INDOLE HCL;1H-Indole, 6-broMo-2,3-dihydro-
• CAS NO: 63839-24-7
• Molecular Formula: C₈H₈BrN
• Molecular Weight: 198.06
• Product Categories: Indoline & Oxindole
• Mol File: 63839-24-7.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 266.325 °C at 760 mmHg
• Flash Point: 114.869 °C
• Appearance: /
• Density: 1.515 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.28±0.20(Predicted)
• CAS DataBase Reference: 6-BROMO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE(63839-24-7)
• EPA Substance Registry System: 6-BROMO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE(63839-24-7)

Safety Data

• Hazard Codes: T
• Statements: 25-51/53-36/37/38
• Safety Statements: 45-61-36-26
• RIDADR: UN2811
• Hazardous Substances Data: 63839-24-7(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white to light brown powder

InChI:InChI=1/C8H8BrN.ClH/c9-7-2-1-6-3-4-10-8(6)5-7;/h1-2,5,10H,3-4H2;1H

Upstream product

• 496-15-1 1-indoline 
• 120-72-9 indole 
• 52415-29-9 6-bromo-1H-indole 
• 99365-40-9 6-bromo-2,3-dihydro-1H-indole-2-one 

Downstream Products

• 1254334-13-8 6-bromo-1-(4-methoxybenzyl)-2,3-dihydro-1H-indole 
• 115666-46-1 6-iodo-2,3-dihydro-1H-indole 
• 15861-35-5 indoline-6-carbonitrile 

Relevant articles and documents

Discovery of an Ultra-rapid and Sensitive Lysosomal Fluorescence Lipophagy Process

Non-invasive dynamic tracking of lysosomes and their interactions with other organelles is important for the study of lysosomal function and related diseases. However, many fluorescent dyes developed so far to target lysosomes cannot be used to monitor these processes due to the high concentrations required for imaging, long cell penetration times, and non-ideal photostability. In this regard, we synthesized three lysosomal targeting probes with large Stokes shifts, good stability, and high brightness. The Q-P-ARh dye, developed by us for the first time, can stain lysosomes at ultra-low concentrations (1.0 nM) without affecting the physiological functions of the lysosomes. More importantly, its excellent anti-interference ability and ultrafast lysosomal staining ability (within 1.0 min) clearly monitored the entire dynamic process of lipophagy. Ultimately, this method can greatly contribute to the study of autophagy pathways. This novel fluorescence platform shows great promise for the development of biological probes for application in pathological environments.

NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION

Nerve-specific fluorophore formulations for direct or systemic administration are described. The formulations can be used in fluorescence-guided surgery (FGS) to aid in nerve preservation during surgical interventions.

RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AS WELL AS PREPARATION METHOD AND USE THEREOF

The present invention relates to a Rho-associated protein kinase inhibitor of Formula (I), a pharmaceutical composition comprising the same, a preparation method thereof, and use thereof for the prevention or treatment of a disease mediated by the Rho-associated protein kinase (ROCK).