63843-42-5

Basic information

• Product Name: 4-(o-tolyloxy)piperidine
• Synonyms: 4-(2-Methylphenoxy) Piperidine Hydrochloride Salt;4-(2-Methylphenoxy)piperidine;4-(2-methylphenoxy)piperidine(SALTDATA: HCl);4-(2-methylphenoxy)piperidine 1HCl;Piperidine, 4-(2-Methylphenoxy)-
• CAS NO: 63843-42-5
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.27
• Mol File: 63843-42-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 293 °C at 760 mmHg
• Flash Point: 118.5 °C
• Appearance: /
• Density: 1.016 g/cm³
• Vapor Pressure: 0.00177mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 4-(o-tolyloxy)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(o-tolyloxy)piperidine(63843-42-5)
• EPA Substance Registry System: 4-(o-tolyloxy)piperidine(63843-42-5)

Safety Data

• Hazardous Substances Data: 63843-42-5(Hazardous Substances Data)

Usage

General Description

4-(o-tolyloxy)piperidine is a chemical compound that consists of a piperidine ring with a substituted ether group attached at the 4-position. The o-tolyloxy group signifies that the substituent is an ortho-substituted tolyloxy, which is a phenyl group with a methoxy substituent in the ortho position. 4-(o-tolyloxy)piperidine has potential pharmaceutical applications due to its piperidine ring, which is a common structural motif in many biologically active molecules. Additionally, the presence of the ether group could make it suitable for use as a building block in the synthesis of other compounds. It is important to handle this compound with caution, as piperidine derivatives can be toxic and are known to have irritant effects.

InChI:InChI=1/C12H17NO/c1-10-4-2-3-5-12(10)14-11-6-8-13-9-7-11/h2-5,11,13H,6-9H2,1H3

Upstream product

• 4727-72-4 1-benzyl-4-hydroxypiperidine 
• 95-52-3 2-Fluorotoluene 
• 95-48-7 ortho-cresol 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 
• 1058702-83-2 tert-butyl 4-(o-tolyloxy)piperidine-1-carboxylate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 

Relevant articles and documents

Identification of a new series of benzothiazinone derivatives with excellent antitubercular activity and improved pharmacokinetic profiles

Nitrobenzothiazinone (BTZ) is a promising scaffold with potent activity against M. tuberculosis by inhibiting decaprenylphosphoryl-beta-d-ribose 2′-oxidase (DprE1). But unfavorable durability poses a challenge to further development of this class of agents. Herein, a series of BTZs bearing a variety of different substituents at the C-2 position were designed and synthesized. Compounds were screened for their antimycobacterial activity against Mycobacterium tuberculosis H37Ra and were profiled for metabolic stability, plasma protein-binding capacity and pharmacokinetics in vivo. In general, these new BTZs containing N-piperazine, N-piperidine or N-piperidone moiety have excellent antitubercular activity and low cytotoxicity. Several of the compounds showed improved microsomal stability and lower plasma protein-binding, opening a new direction for further lead optimization. And we obtained compound 3o, which maintained good anti-tuberculosis activity (MIC = 8 nM) and presented better in vitro ADME/T and in vivo pharmacokinetic profiles than reported BTZ compound PBTZ169, which may serve as a candidate for the treatment of tuberculosis.

DERIVATIVES OF TRIAZINES AND URACILS, THEIR PREPARATION AND THEIR APPLICATION IN HUMAN THERAPEUTICS

The present invention relates to derivatives of general formula I wherein : - W represents nitrogen, - R1 represents: ? a hydrogen or a linear or branched C1-C5 alkyl radical or, ? a C1-C3 alkyl radical substituted with groups such as trifluoromethyl, nitrile, hydroxy, C1-C3 alcoxy, C3-C6 alkoxyalkoxy, indolyl, thiophenyl, oxothiophenyl, C1-C3 N-alkylcarbamoyl groups or, ? a phenyl or pyridyl or naphthyl, or thiophenyl group optionally substituted with one or more groups such as halogen atoms, nitro, nitrile, trifluoromethyl, vinyl, methylsulfanyl, linear branched C1-C4 alkyl, linear or branched C1-C3 alkoxy groups, ? a C6 2-oxocycloalkyl radical - R2 represents a methyl or heptyl, - m, n are equal to 1, - V represents CH2, - X-Y represents -N- (C=O) -, -CH-O-, - Z represents a phenyl group substituted with one or more trifluoromethyl groups, halogen atoms or linear C1-C4 alkyl groups.

Method of treating pain and hypertension

3-[2-(Phenyloxycycloazalkyl)ethyl]indoles possessing antihypertensive, analgesic, and tranquilizing properties and process for their preparation are described.