63843-53-8

Basic information

• Product Name: 4-(3-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE
• Synonyms: 4-(3-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE;4-(4-chlorophenoxy)piperidine HCl
• CAS NO: 63843-53-8
• Molecular Formula: C₁₁H₁₄ClNO*ClH
• Molecular Weight: 248.15
• Mol File: 63843-53-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 345.2 °C at 760 mmHg
• Flash Point: 162.6 °C
• Appearance: /
• Vapor Pressure: 4.42E-05mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-(3-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE(63843-53-8)
• EPA Substance Registry System: 4-(3-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE(63843-53-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36-52
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 63843-53-8(Hazardous Substances Data)

Usage

General Description

4-(3-Chlorophenoxy)piperidine hydrochloride is a chemical compound with the molecular formula C11H15Cl2NO. It is a piperidine derivative with a chlorophenyl group attached to the piperidine ring. 4-(3-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE is commonly used in research and pharmaceutical applications. It acts as an antagonist at the serotonin 5-HT2A receptor and has potential applications in the treatment of various psychiatric disorders. It is also used as a building block for the synthesis of other chemical compounds. 4-(3-Chlorophenoxy)piperidine hydrochloride is available in the form of a white to off-white powder and should be handled and stored according to standard safety protocols.

InChI:InChI=1/C11H14ClNO.ClH/c12-9-1-3-10(4-2-9)14-11-5-7-13-8-6-11;/h1-4,11,13H,5-8H2;1H

Upstream product

• 106-48-9 4-chloro-phenol 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 333954-83-9 tert-butyl 4-(4-chlorophenoxy)piperidine-1-carboxylate 

Downstream Products

• 1304787-84-5 (4-(4-chlorophenoxy)piperidin-1-yl)(1H-indol-5-yl)methanone 
• 1304787-83-4 3-(tert-butyl)-5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)benzoic acid 
• 1304783-85-4 3-(tert-butyl)-5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)benzamide 
• 1304787-90-3 methyl 3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)benzoate 
• 1304783-57-0 (4-(aminomethyl)pyridin-2-yl)(4-(4-chlorophenoxy)piperidin-1-yl)methanone 
• 1304783-58-1 N-((2-(4-(4-chlorophenoxy)piperidine-1-carbonyl)pyridin-4-yl)methyl)pivalamide 
• 1304783-93-4 (4-(4-chlorophenoxy)piperidin-1-yl)(1-(2-morpholinoethyl)-1H-indol-5-yl)methanone 
• 1304787-85-6 (1-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1H-indol-5-yl)(4-(4-chlorophenoxy)piperidin-1-yl)methanone 
• 1304783-95-6 (4-(4-chlorophenoxy)piperidin-1-yl)(1-(2-hydroxyethyl)-1H-indol-5-yl)methanone 
• 1304787-86-7 tert-butyl (2-(5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1H-indol-1-yl)ethyl)carbamate 
• 1304784-25-5 (1-(2-aminoethyl)-1H-indol-5-yl)(4-(4-chlorophenoxy)piperidin-1-yl)methanone 
• 1304784-26-6 N-(2-(5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1H-indol-1-yl)ethyl)acetamide 
• 1304787-87-8 methyl 4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)benzoate 
• 1304787-88-9 4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)benzoic acid 

Relevant articles and documents

Development of a Practical Process for the Synthesis of PDE4 Inhibitors

A practical, safe, and efficient process for the synthesis of PDE4 (phosphodiesterase type 4) inhibitors represented by 1 and 2 was developed and demonstrated on a multi-kilogram scale. Key aspects of the process include the regioselective synthesis of dihydrothieno[3,2-d]pyrimidine-2,4-diol 9 and the asymmetric sulfur oxidation of intermediate 11.

NEW BENZOYL UREA DERIVATIVES

The new benzoyl urea derivatives of formula (I) wherein the meaning of X and Y independently are hydrogen atom, hydroxy, benzyloxy, amino, nitro, C1-C4 alkylsulfonamido optionally substituted with a halogen atom or halogen atoms, Cs

Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use

The subject invention provides compounds having the structure: 1 wherein,R1 is a substituted or unsubstituted alkyl, wherein the substituent is hydroxyl, dihydroxy, carboxyl, —C(═O)NRaRb, —NRaRb, —NRaC(═O)NRaRb, —NRaC(═O)ORa, —OC(═O)NRaRb, or —NHC(═O)Ra;R2 is hydrogen or a substituted or unsubstituted alkyl, wherein the substituent is hydroxyl, dihydroxy, carboxyl, —C(═O)NRaRb, —NRaRb, —NRaC(═O)NRaRb, —NRaC(═O)ORa, —OC(═O)NRaRb, or —NHC(═O)Ra, orR1, R2 and N together form a substituted piperazine, substituted azetidine ring, or a pyrrolidine ring substituted with —(CH2)2OH or —CH2C(═O)OH;R3 is a substituted or unsubstituted phenyl or a 5-6 membered heteroaryl ring, wherein the substituent is halogen, hydroxyl, cyano, (C1-C15)alkyl, (C1-C15)alkoxy, or —NRaRb;R4 is hydrogen or substituted or unsubstituted (C1-C15)alkyl;R5 is —(CH2)mOR6, —CHNOR7, —C(═O)NR8R9, —(CH2)mC(═O)OR10, —(CH2)kC(═O)NR11R12;wherein R6 is a substituted or unsubstituted (C1-C30)alkyl, (C3-C10)cycloalkyl, or an aryl, heteroaryl or 4-8 membered heterocyclic ring;R7 is hydrogen, or a substituted or unsubstituted (C1-C30)alkyl, (C1-C30)alkylaryl;R8 and R9 are each independently hydrogen, or a substituted or unsubstituted (C1-C30)alkyl, (C1-C30)alkylaryl, (C1-C30)alkylamino, (C1-C30)alkoxy, or a saturated or unsaturated, monocyclic or bicyclic, carbocyclic or heterocyclic ring, orR8, N, and R9 together form a substituted or unsubstituted 4-8 membered heterocyclic ring;R10 is hydrogen or a substituted or unsubstituted (C1-C30)alkyl, (C3-C10)cycloalkyl, or an aryl, heteroaryl or heterocyclic ring;R11, N and R12 together form a 4-8 membered heterocyclic ring;Ra and Rb are each independently hydrogen or alkyl;m is 0, 1, 2 or 3; andk is 1, 2 or 3,or a specific enantiomer thereof, or a specific tautomer thereof, or a pharmaceutically acceptable salt thereof, and a method for treating a disease associated with the A2b adenosine receptor in a subject in need of such treatment comprising administering to the subject a therapeutically effective amount of the compounds of the invention.