63844-77-9Relevant academic research and scientific papers
Isolation and characterization of the product of inactivation of γ-aminobutyric acid aminotransferase by gabaculine
Fu, Mengmeng,Silverman, Richard B.
, p. 1581 - 1590 (1999)
Gabaculine (5-amino-1,3-cyclohexadienylcarboxylic acid, 1Scheme 1), a naturally occurring neurotoxin isolated from Streptomyces toyocaenis, has been shown to be a mechanism-based inactivator of γ-aminobutyric acid aminotransferase (GABA-AT) (Rando, R. R.
Transition-state analogues as inhibitors for GABA-aminotransferase
Iskander, MN,Andrews, PR,Winkler, DA,Brinkworth, RI,Paola, C Di,et al.
, p. 129 - 136 (2007/10/02)
Our previous calculations on the reaction catalysed by GABA-aminotransferase (GABA-T) have been utilized in this work in order to synthesize a series of reversible inhibitors of this enzyme.The synthesized transition-state analogues and their precursors i
