63868-67-7Relevant academic research and scientific papers
Design and synthesis of gallocyanine inhibitors of DKK1/LRP6 interactions for treatment of Alzheimer's disease
Thysiadis, Savvas,Katsamakas, Sotirios,Mpousis, Spyros,Avramidis, Nicolaos,Efthimiopoulos, Spiros,Sarli, Vasiliki
, p. 230 - 244 (2018/07/03)
Based on NCI8642, a series of gallocyanine derivatives was synthesized with modifications of the substituent groups in position 1, 2 and 4 of the phenoxazinone scaffold. The effectiveness of gallocyanines to inhibit DKK1/LRP6 interactions and Tau phosphorylation induced by prostaglandin J2 and DKK1 was elucidated by both experimental data and molecular docking simulations. Bis-alkylated with flexible alkyl ester groups on C1 and bis-benzyl gallocyanines provided the most active inhibitors, while amino derivatives on C2 of NCI8642 that have alkoxy or benzyloxy substituents on C4, were less active. Furthermore, it is shown that treating of SHSY5Y cells with NCI8642 derivatives activates Wnt signaling and increases the levels of pGSK3β kinase and β-catenin.
Synthesis, crystal structure and anti-fatigue effects of some benzamide derivatives
Wu, Xianglong,Fan, Wutu,Pan, Yalei,Zhai, Yuankun,Niu, Yinbo,Li, Chenrui,Mei, Qibing
, p. 1034 - 1046 (2014/02/14)
A series of benzamide derivatives such as 1-(1,3-benzodioxol-5-ylcarbonyl) piperidine (1-BCP) were synthesized by the reaction of substituted benzoic acids with piperidine, morpholine or pyrrolidine using a novel method. The crystals of these benzamide de
