63877-69-0Relevant academic research and scientific papers
Microwave solvent-free synthesis of nitrocyclohexanols
Correc, Olivier,Guillou, Karine,Hamelin, Jack,Paquin, Ludovic,Texier-Boullet, Fran?oise,Toupet, Lo?c
, p. 391 - 395 (2007/10/03)
New nitrocyclohexanols 3a-f are synthesized by a clean and original method from nitromethane 1 and unsaturated ketones 2a-f in the presence of solid potassium fluoride-alumina under solvent-free conditions coupled with microwave irradiation. The reaction involves a double and diastereoselective Michael addition followed by ring closure. Another diastereomer 3′, which differs by the configuration of C-4, is obtained in the presence of piperidine and EtOH at room temperature.
Asymmetric Induction in the Michael Reaction by Means of Chiral Phase-transfer Catalysts derived from Cinchona and Ephedra Alkaloids
Colonna, Stefano,Re, Alberto,Wynberg, Hans
, p. 547 - 552 (2007/10/02)
Asymmetric induction in the Michael reaction has been achieved using alkaloidonium salts in a two-phase system with optical yields of up to 36 and 26percent in the addition to αβ-unsaturated ketones of thiols and nitroalkanes respectively.The presence of a hydroxy-group β to the 'onium function is essential to achieve substantial asymmetric syntheses.
