63878-68-2

Usage

Uses

Used in Pharmaceutical Industry:
1-Fluoro-2-(fluoroMethyl)-4-nitrobenzene is used as an intermediate in the manufacturing of pharmaceuticals for its reactivity and ability to participate in various chemical reactions, contributing to the synthesis of diverse medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Fluoro-2-(fluoroMethyl)-4-nitrobenzene is utilized as an intermediate in the production of agrochemicals, playing a role in the synthesis of compounds that can be used in pest control and crop protection.
Used in Organic Compounds Synthesis:
1-Fluoro-2-(fluoroMethyl)-4-nitrobenzene is used as a reactive intermediate in the synthesis of various organic compounds, owing to its capacity to engage in multiple chemical reactions, thus broadening its applications in organic chemistry.
Safety Precautions:
It is important to handle 1-Fluoro-2-(fluoroMethyl)-4-nitrobenzene with care due to its potential hazards. 1-Fluoro-2-(fluoroMethyl)-4-nitrobenzene can be harmful if inhaled, swallowed, or absorbed through the skin, and it may cause irritation to the eyes and skin upon contact. Proper safety measures should be taken to minimize risks during its use in various applications.

Upstream product

• 63878-73-9 (2-fluoro-5-nitrophenyl)methanol 
• 455-88-9 5-nitro-2-fluorotoluene 
• 27996-87-8 2-fluoro-5-nitrobenzaldehye 

Downstream Products

• 1445796-35-9 4-fluoro-3-(fluoromethyl)aniline 
• 1572511-08-0 C₁₈H₁₈F₂N₂O₄S 

Relevant academic research and scientific papers

SULFAMOYL-ARYLAMIDES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B

Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R1, R2 and R4 have the meaning as defined herein. The present invention also relates to pharmaceutical compositions containing these inhibitors and to their use, alone or in combination with other HBV inhibitors, in HBV therapy.

SULFAMOYL-ARYLAMIDES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B

Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R1, R2 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.

HEPATITIS B ANTIVIRAL AGENTS

The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.

Selective electrolytic fluorinations in 70% HF/30% pyridine

The selective fluorination of compounds containing benzylic hydrogen atoms was accomplished by electrolysis in a mixture of 70% HF and 30% pyridine (Olah's reagent) using a square wave alternating current (1.76-2.75 V, 0.02-0.05 Hz) and Pt electrodes. This method can be used in the laboratory to prepare conveniently gram-size quantities of monofluorinated products. An ion radical mechanism has been proposed.