6390-59-6Relevant academic research and scientific papers
Oxidative photocatalytic homo- And cross-coupling of phenols: Nonenzymatic, catalytic method for coupling tyrosine
Niederer, Kyle A.,Gilmartin, Philip H.,Kozlowski, Marisa C.
, p. 14615 - 14623 (2020/12/23)
An oxidative photocatalytic method for phenol? phenol homo- and cross-coupling is described, and isolated yields of 16?97% are obtained. Measured oxidation potentials and computed nucleophilicity parameters support a mechanism of nucleophilic attack of one partner onto the oxidized neutral radical form of the other partner. Our understanding of this model permitted the development of cross-coupling reactions between nucleophilic phenols/arenes and easily oxidized phenols with high selectivity and efficiency. A highlight of this method is that one equivalent of each coupling partner is utilized. Building on these findings, a nonenzymatic, catalytic method for coupling tyrosine was also developed.
PROCESS FOR PREPARING 2,2'-SELENOBIARYL ETHERS OR 4,4'-SELENOBIARYL ETHERS USING SELENIUM DIOXIDE
-
Paragraph 0149; 0150; 0168-0179; 0223, (2015/12/05)
A process for preparing a 2,2′-selenobiaryl ether or a 4,4′-selenobiaryl ether, proceeds by a) adding a first phenol to the reaction mixture, b) adding a second phenol to the reaction mixture, c) adding selenium dioxide to the reaction mixture, d) adding a base having a pKb in the range from 8 to 11 to the reaction mixture, and e) adjusting the reaction temperature of the reaction mixture such that the first phenol and the second phenol are converted to said 2,2′-selenobiaryl ether or said 4,4′-selenobiaryl ether.
