63901-83-7

Basic information

• Product Name: 3-FT
• Synonyms: 3-FT;3-(Tetrahydrofuran-2-yl)-5-fluorouracil;5-Fluoro-3-(tetrahydrofuran-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione;5-Fluoro-3-(tetrahydrofuran-2-yl)uracil
• CAS NO: 63901-83-7
• Molecular Formula: C₈H₉FN₂O₃
• Molecular Weight: 200.19
• Mol File: 63901-83-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.45g/cm³
• Refractive Index: 1.557
• CAS DataBase Reference: 3-FT(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FT(63901-83-7)
• EPA Substance Registry System: 3-FT(63901-83-7)

Safety Data

• Hazardous Substances Data: 63901-83-7(Hazardous Substances Data)

Usage

Hazard

Moderately toxic by ingestion.

InChI:InChI=1/C8H9FN2O3/c9-5-4-10-8(13)11(7(5)12)6-2-1-3-14-6/h4,6H,1-3H2,(H,10,13)

Upstream product

• 1608-67-9 2-acetoxytetrahydrofuran 
• 51-21-8 5-fluorouracil 
• 90162-90-6 1-(octylthio)carbonyl-3-(tetrahydrofuryl)-5-fluorouracil 
• 75-31-0 isopropylamine 

Relevant articles and documents

Synthesis of Tegafur by the Alkylation of 5-Fluorouracil under the Lewis Acid and Metal Salt-Free Conditions

A novel protocol for preparation of tegafur (a prodrug of 5-fluorouracil) is reported. The process involves the 1,8-diazabicycloundec-7-ene-mediated alkylation of 5-fluorouracil with 2-acetoxytetrahydrofuran at 90 °C, followed by treatment of the prepurified mixture of the alkylation products with aqueous ethanol at 70 °C. The yield of the two-step process is 72%.

Anti-cancer composition for delivering 5-fluorouracil

An anti-cancer composition comprising a 5-fluorouracil (including derivatives thereof) and uracil (or salt thereof), is disclosed, wherein the composition contains less than 0.1 mole of the 5-fluorouracil per mole of the uracil.

Synthesis of tetrahydro-2-furyl derivatives of 5-substituted uracils

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