639087-58-4Relevant articles and documents
Folding of phosphodiester-linked donor-acceptor oligomers into supramolecular nanotubes in water
Pérez De Carvasal, Kévan,Aissaoui, Nesrine,Vergoten, Gérard,Bellot, Ga?tan,Vasseur, Jean-Jacques,Smietana, Michael,Morvan, Fran?ois
, p. 4130 - 4133 (2021)
Inspired by the automated synthesis of DNA on a solid support, the electron-rich dialkoxynaphthalene (DAN) donor and the electron-deficient naphthalene-tetracarboxylic diimide (NDI) acceptor, amphiphilic foldamers have been synthesised from their respecti
Development of donor-acceptor modified DNA hairpins for the investigation of charge hopping kinetics in DNA
Rahe, Nicole,Rinn, Cornelia,Carell, Thomas
, p. 2120 - 2121 (2003)
Investigation of hole or excess electron hopping in DNA is mostly performed based on yield studies, in which an injector modified DNA duplex is irradiated to continuously inject either holes or electrons into the duplex. Observed is a chemical reaction of a "probe" molecule, which can be either one of the two purine bases or a different trap molecule positioned at various distances. The next step in the field will be the direct time resolution of the hole or electron transfer kinetics in DNA. Herein we describe the development of defined donor-DNA-acceptor systems, with properties that may allow time resolved electron and hole transfer studies in stably folded DNA structures.
Selectively Addressable Photogenerated Spin Qubit Pairs in DNA Hairpins
Olshansky, Jacob H.,Zhang, Jinyuan,Krzyaniak, Matthew D.,Lorenzo, Emmaline R.,Wasielewski, Michael R.
, p. 3346 - 3350 (2020)
Photoinduced electron transfer can produce radical pairs having two quantum entangled electron spins that can act as spin qubits in quantum information applications. Manipulation of these spin qubits requires selective addressing of each spin using microw
Specific nonpeptide inhibitors of puromycin-sensitive aminopeptidase with a 2,4(1H,3H)-quinazolinedione skeleton.
Kakuta, Hiroki,Tanatani, Aya,Nagasawa, Kazuo,Hashimoto, Yuichi
, p. 1273 - 1282 (2007/10/03)
Potent, specific, chemically stable and non-peptide/small-molecular inhibitors of puromycin-sensitive aminopeptidase, such as 3-(2,6-diethylphenyl)-2,4(1H,3H)-quinazolinedione (PAQ-22, 5), were prepared by the structural development of a potent PSA inhibitor, 2-(2,6-diethylphenyl)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (PIQ-22, 4). The design was carried out partly by applying electrostatic potential field information obtained from PIQ-22 (4) and its derivatives based on thalidomide (2). This information revealed that a positive electrostatic potential field around the benzylic methylene in the tetrahydroisoquinoline ring is necessary for potent activity. Lineweaver-Burk plot analysis showed that PAQ-22 (5) and its derivatives inhibit puromycin-sensitive aminopeptidase (PSA) in a non-competitive manner. These potent and specific PSA inhibitors showed dose-dependent cell invasion-inhibitory activity in a Matrigel assay using mouse melanoma B16F10/L5 cells, in spite of their low cell toxicity.