6392-26-3

Usage

Uses

Used in Pharmaceutical Industry:
(2-CHLORO-PHENYL)-MORPHOLIN-4-YL-METHANONE is used as an intermediate in the synthesis of various pharmaceuticals for its potential role in the development of new drugs with diverse biological activities. Its unique structure, including the chloro group and morpholine ring, allows for the creation of compounds that can target specific biological pathways or receptors.
Used in Agrochemical Industry:
(2-CHLORO-PHENYL)-MORPHOLIN-4-YL-METHANONE is also used as an intermediate in the synthesis of agrochemicals, contributing to the development of new pesticides or other agricultural products. Its chemical properties make it a valuable component in creating effective and targeted agrochemicals.
It is important to handle (2-CHLORO-PHENYL)-MORPHOLIN-4-YL-METHANONE with care, as it may pose health and environmental hazards. Proper safety measures should be taken during its production, use, and disposal to minimize any potential risks.

InChI:InChI=1/C11H12ClNO2/c12-10-4-2-1-3-9(10)11(14)13-5-7-15-8-6-13/h1-4H,5-8H2

Upstream product

• 110-91-8 morpholine 
• 609-65-4 o-chlorobenzoyl chloride 
• 15159-40-7 4-morpholinocarbonyl chloride 
• 346656-42-6 2-(2-chlorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane 
• 68388-08-9 2-chlorobenzoic acid N-hydroxysuccinimide ester 
• 89-98-5 2-chloro-benzaldehyde 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 23328-69-0 4-chloromorpholine 
• 95-49-8 2-methylchlorobenzene 
• 615-41-8 2-iodochlorobenzene 
• 13939-06-5 molybdenum hexacarbonyl 
• 17849-38-6 2-Chlorobenzyl alcohol 
• 118-91-2 ortho-chlorobenzoic acid 

Downstream Products

• 6391-91-9 o-chlorobenzothiomorpholide 
• 1386231-41-9 potassium 2-(morpholine-4-carbonyl)phenyltrifluoroborate 
• 874219-17-7 [2-(morpholin-4-ylcarbonyl)phenyl]boronic acid 
• 622370-35-8 [2-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-(4-pyridinyl)-1H-1,2,3-triazol-4-yl]-3-pyridinyl](2-chlorophenyl)-methanone 
• 622372-89-8 (2-bromo-pyridin-3-yl)-(2-chloro-phenyl)-methanone 
• 1400974-96-0 4'-(1H-pyrrol-1-yl)([1,1'-biphenyl]-2-yl)(morpholino)methanone 

Relevant academic research and scientific papers

Solar and visible-light active nano Ni/g-C3N4photocatalyst for carbon monoxide (CO) and ligand-free carbonylation reactions

In this study, we investigate the amino and alkoxycarbonylation reaction between various substituted aryl halides, benzyl iodides, and iodocyclohexane with different types of amines and alcohols in the absence of carbon monoxide gas and ligands. Similar reactions are carried out at high temperatures, in the presence of appropriate ligands, stoichiometric amounts of bases, and gaseous carbon monoxide, which endanger the health of organic chemists. We present a novel method that does not utilize ligands, bases, gaseous CO, and special conditions. This procedure is a redox reaction carried out by new economic nano Ni/g-C3N4at room temperature and under visible light. Mo(CO)6was used toin situgenerate CO, to resolve the problems caused by the use of CO gas. This protocol has the ability to be used on a gram scale by using a continuous flow reactor.

Two-step continuous flow synthesis of amide via oxidative amidation of methylarene

A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separately. Oxidation with tert-butyl hydroperoxide (TBHP) as “green” oxidant, the synthesis of amides under mild reaction conditions in continuous flow system and the utilization of methylarenes as starting material make this methodology novel and environment friendly. The practical value of this method is highlighted through the synthesis of high-profile pharmaceutical agents, acetylprocainamide.

Carbon bridged bis-amide-based rare-earth amine compound and its preparation and with [...][...] synthesis reaction in the application of the

The invention discloses a carbon-bridged diacylamino rare earth amide with a general formula of {LLn[N(SiMe3)2]}2, wherein Ln is a rare earth metal selected from lanthanum, neodymium, samarium and yttrium, L represents a carbon-bridged diacylamino ligand, and n may be 1, 2 or 3 and can represent different ligands. The chemical structural formula of the carbon-bridged diacylamino rare earth amide differs with changes of the rare earth metal and the ligand. The invention targetedly discloses four chemical structural formulas of the rare earth amide as shown in the general formula. The carbon-bridged diacylamino rare earth amide provided by the invention is simple to synthesize, has definite structure and high yield and is easy to separate and purify. The invention also provides a preparation method for the rare earth amide and a method for applying the rare earth amide as a catalyst for catalysis of amidation of aldehyde and amine. The application method has the advantages of mild conditions, high activity, good selectivity, a wide substrate adaptation scope, a small catalyst amount and high product yield.

Design, synthesis and evaluate in vitroantifungal activity of novel benzamide derivatives

Summary: A series of novel benzamide derivatives according to fluopicolide were designed and synthesized following the rule of combination carboxylic acid amides and amines derivatives together. The antifungal activity of the 15 new compounds were evaluated in vitroagainst five pathogenic fungi, including Sclerotinia sclerotiorum,Gibberella zeae, Rhizoctonia solani, Helminthosporium maydisand Botrytis cinerea. Almost all the structure have not been reported, except compounds 3, 5and 6. A surprising finding is that all the five tested fungi breed faster than negative controls when supplementary with compound 7-15, respectively.

PROCESS DEVELOPMENT OF A PYRIDINE-CONTAINING NK-1 RECEPTOR ANTAGONIST

The disclosure provides process developments and novel routes for the preparation of the NK-1 receptor antagonist, Compound (I) and intermediates in those routes.

Ortho lithiation-in situ borylation of substituted morpholine benzamides

Morpholine amides are cheap and safe alternative to Weinreb amides as acylating agents of organometallic species. Herein, the in-situ lithiation/borylation of 18 ortho- meta- and para-substituted morpholine benzamides has been investigated. 10 of the 18 substrates provided the desired boronic esters as the major isomer (>90% regioselectivity) in crude isolated yields ranging from 68 to 93%. The synthetic usability of such building blocks was subsequently illustrated via the synthesis of a kinase inhibitor.

Synthesis and characterization of bridged bis(amidato) rare earth metal amides and their applications in C-N bond formation reactions

Based on three bisamide proligands H2Ln (n = 1-3) (H2L1 = [(Me3C6H2CONHCH2)2CH2], H2L2 = [(Me3C6H2CONHCH2)2C(CH3)2], H2L3 = [Me3C6H2CONH(CH2)2]2NCH3), eight bis(amidato) trivalent rare-earth metal amides {LnRE[N(TMS)2]}2 (n = 1, RE = La (1), Sm (2), Nd (3), Y (4); n = 2, RE = La (5), Nd (6); n = 3, RE = La (7), Nd (8); TMS = SiMe3) were successfully synthesized by treatment of H2Ln with RE[N(TMS)2]3 in a 1:1 molar ratio. Complexes 3, and 5-8 were characterized by single-crystal X-ray diffraction, and NMR characterization was carried out for the La complexes 1, 5, 7 and the Y complex 4. These complexes exhibited high catalytic activities in both the direct amidation of aldehydes and the addition of amines with carbodiimine. It was found that the bis(amidato) rare earth metal amides bearing different linkers have different effects on the transformations and lanthanum and neodymium complexes performed better than others.

Copper-catalyzed and iodide-promoted aerobic C-C bond cleavage/C-N bond formation toward the synthesis of amides

A copper-catalyzed and iodide-promoted aerobic C-C bond cleavage/C-N bond formation reaction between ketone and simple amine was developed toward the synthesis of amides, which are useful synthetic intermediates in organic synthesis and important skeletons of biologically active molecules. Notably, the reaction conditions are very mild, and preliminary mechanistic investigations indicate that molecular oxygen might be involved in the C-C bond cleavage process.

A two-step continuous flow synthesis of amides from alcohol using a metal-free catalyst

Metal-free oxidative amination of aromatic alcohols in the presence of TBHP provides convenient access to amides in 86-96% yield under mild reaction conditions within 15 min in a two-step continuous flow reactor system. This method avoids expensive transition metal catalysts and integrates alcohol oxidation and amide bond formation, which are usually accomplished separately, into a single operation.

A copper-catalysed amidation of aldehydes via N-hydroxysuccinimide ester formation

A copper-catalysed oxidative amidation of aldehydes via N-hydroxysuccinimide ester formation is reported. The methodology employed to prepare amides directly from aldehydes has a very wide scope, is high yielding, and does not need dry conditions. This cross-coupling reaction appears to be simple and makes use of cheap, abundant and easily available reagents.