63930-81-4Relevant academic research and scientific papers
TRICYCLIC PYRAZOLE KINASE INHIBITORS
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Page/Page column 57, (2008/06/13)
Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Synthesis of unsymmetrical dinucleating ligands bearing nitrogen and oxygen donor atoms
Fenton, David E.,Papageorgiou, George
, p. 5913 - 5928 (2007/10/03)
The synthesis of unsymmetrical dinucleating ligands bearing nitrogen and oxygen donor atoms is described. The Schiff-base condensation of functionalised salicylaldehyde derivatives with primary amines gave rise to unsymmetrical unsaturated ligands, whereas condensation with secondary amines followed by in situ reduction of the iminium species with sodium borohydride, led to the formation of unsymmetrical saturated ligands. The latter were also prepared by the tandem Mannich reactions of 4-chlororesorcinol.
