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  • 63945-11-9 Structure
  • Basic information

    1. Product Name: N-(6-hydroxyhexyl)-phthalimide
    2. Synonyms: N-(6-hydroxyhexyl)-phthalimide
    3. CAS NO:63945-11-9
    4. Molecular Formula: C14H17NO3
    5. Molecular Weight: 247
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 63945-11-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(6-hydroxyhexyl)-phthalimide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(6-hydroxyhexyl)-phthalimide(63945-11-9)
    11. EPA Substance Registry System: N-(6-hydroxyhexyl)-phthalimide(63945-11-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 63945-11-9(Hazardous Substances Data)

63945-11-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 63945-11-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,9,4 and 5 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 63945-11:
(7*6)+(6*3)+(5*9)+(4*4)+(3*5)+(2*1)+(1*1)=139
139 % 10 = 9
So 63945-11-9 is a valid CAS Registry Number.

63945-11-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(6-hydroxyhexyl)isoindole-1,3-dione

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:63945-11-9 SDS

63945-11-9Relevant articles and documents

Visible-Light-Driven Dehydrogenative Coupling of Primary Alcohols with Phenols Forming Aryl Carboxylates

Ishida, Naoki,Kawasaki, Tairin,Murakami, Masahiro,Tosaki, Tomohiro

supporting information, p. 7683 - 7687 (2021/10/12)

A preparative method for obtaining aryl esters from aliphatic primary alcohols and phenols was developed. The reaction proceeds under the irradiation of visible light at ambient temperature, dispensing with any oxidant or hydrogen acceptor. Primary alcohols having a variety of functional groups are successfully esterified with phenols. The produced esters can be utilized as the precursor of various carbonyl compounds.

Live-Cell Protein Modification by Boronate-Assisted Hydroxamic Acid Catalysis

Adamson, Christopher,Kajino, Hidetoshi,Kanai, Motomu,Kawashima, Shigehiro A.,Yamatsugu, Kenzo

supporting information, p. 14976 - 14980 (2021/09/29)

Selective methods for introducing protein post-translational modifications (PTMs) within living cells have proven valuable for interrogating their biological function. In contrast to enzymatic methods, abiotic catalysis should offer access to diverse and new-to-nature PTMs. Herein, we report the boronate-assisted hydroxamic acid (BAHA) catalyst system, which comprises a protein ligand, a hydroxamic acid Lewis base, and a diol moiety. In concert with a boronic acid-bearing acyl donor, our catalyst leverages a local molarity effect to promote acyl transfer to a target lysine residue. Our catalyst system employs micromolar reagent concentrations and affords minimal off-target protein reactivity. Critically, BAHA is resistant to glutathione, a metabolite which has hampered many efforts toward abiotic chemistry within living cells. To showcase this methodology, we installed a variety of acyl groups inE. colidihydrofolate reductase expressed within human cells. Our results further establish the well-known boronic acid-diol complexation as abona fidebio-orthogonal reaction with applications in chemical biology and in-cell catalysis.

Selective hydroboration of equilibrating allylic azides

Liu, Ruzhang,Xu, Jun,Zhang, Yuanyuan

supporting information, p. 8913 - 8916 (2021/09/13)

The iridium(i)-catalyzed hydroboration of equilibrating allylic azides is reported to provide only the anti-Markovnikov product of alk-1-ene isomers in good yields and with good functional group tolerance.

Catalytic Acceptorless Dehydrogenation of Aliphatic Alcohols

Fuse, Hiromu,Mitsunuma, Harunobu,Kanai, Motomu

supporting information, p. 4493 - 4499 (2020/03/05)

We developed the first acceptorless dehydrogenation of aliphatic secondary alcohols to ketones under visible light irradiation at room temperature by devising a ternary hybrid catalyst system comprising a photoredox catalyst, a thiophosphate organocatalyst, and a nickel catalyst. The reaction proceeded through three main steps: hydrogen atom transfer from the α-C-H bond of an alcohol substrate to the thiyl radical of the photo-oxidized organocatalyst, interception of the generated carbon-centered radical with a nickel catalyst, and β-hydride elimination. The reaction proceeded in high yield under mild conditions without producing side products (except H2 gas) from various alcohols, including sterically hindered alcohols, a steroid, and a pharmaceutical derivative. This catalyst system also promoted acceptorless cross-dehydrogenative esterification from aldehydes and alcohols through hemiacetal intermediates.

Non-imidazole histamine H3 Ligands. Part VII. Synthesis, in vitro and in vivo characterization of 5-substituted-2-thiazol-4-n-propylpiperazines

Guryn, Roman,Staszewski, Marek,Stasiak, Anna,Flores, Daniel McNaught,Fogel, Wies?awa Agnieszka,Leurs, Rob,Walczynski, Krzysztof

, (2018/02/14)

H3 receptors present on histaminergic and non-histaminergic neurons, act as autoreceptors or heteroreceptors controlling neurotransmitter release and synthesis. Previous, studies have found that the compound N-methyl-N-3-phenylalkyl-2-[2-(4-n-propylpiperazin-1-yl)-1,3-thiazol-5-yl]ethan-1 -amine (ADS-531, 2c) exhibits high in vitro potency toward H3 Guinea pig jejunal receptors, with pA2 = 8.27. To optimize the structure of the lead compound ADS-531, a series of 5-substituted-2-thiazol-4-n-propylpiperazines 3 were synthesized and subjected to in vitro pharmacological characterization; the alkyl chain between position 2 of the thiazole ring and the terminal secondary N-methylamino function was elongated from three to four methylene groups and the N-methylamino functionality was substituted by benzyl-, 2-phenylethyl-, and 3-phenyl-propyl- moieties. SAR studies on novel non-imidazole, 5-substituted-2-thiazol-4-n-propyl-piperazines 3 showed that the most active compound 3a (pA2 = 8.38), additionally possessed a weak competitive H1-antagonistic activity. Therefore, compound ADS-531, which did not exhibit any H1-antagonistic activity, was chosen for further evaluation for its affinity to the recombinant rat and human histamine H3 receptors (rH3R and hH3R, respectively). ADS-531 exhibited nanomolar affinity for both rH3R and hH3R receptors. It was also shown that, ADS-531 given subchronically to rats (s.c. 3 mg/kg, 5 days) penetrated the brain, where it affected dopamine, noradrenaline and serotonin concentration; however, it did not affect histamine concentration nor feeding behavior.

IMINOSUGARS USEFUL FOR THE TREATMENT OF VIRAL DISEASES

-

Page/Page column 93; 94, (2016/06/01)

Formula IA, ad their use for treating viral infections.

Nucleoside analogues with a 1,3-diene-Fe(CO)3 substructure: Stereoselective synthesis, configurational assignment, and apoptosis-inducing activity

Hirschh?user, Christoph,Velcicky, Juraj,Schlawe, Daniel,Hessler, Erik,Majdalani, André,Neud?rfl, J?rg-Martin,Prokop, Aram,Wieder, Thomas,Schmalz, Hans-Günther

supporting information, p. 13017 - 13029 (2013/10/01)

The synthesis and stereochemical assignment of two classes of iron-containing nucleoside analogues, both of which contain a butadiene-Fe(CO)3 substructure, is described. The first type of compounds are Fe(CO)3-complexed 3'-alkenyl-2′,3′-dideoxy- 2′,3′-dehydro nucleosides (2,5-dihydrofuran derivatives), from which the second class of compounds is derived by formal replacement of the ring oxygen atom by a CH2 group (carbocyclic nucleoside analogues). These compounds were prepared in a stereoselective manner through the metal-assisted introduction of the nucleobase. Whilst the furanoid intermediates were prepared from carbohydrates (such as methyl-glucopyranoside), the carbocyclic compounds were obtained by using an intramolecular Pauson-Khand reaction. Stereochemical assignments based on NMR and CD spectroscopy were confirmed by X-ray structural analysis. Biological investigations revealed that several of the complexes exhibited pronounced apoptosis-inducing properties (through an unusual caspase 3-independent but ROS-dependent pathway). Furthermore, some structure-activity relationships were identified, also as a precondition for the design and synthesis of fluorescent and biotin-labeled conjugates. I gotta Fe-ling: Iron-containing nucleoside analogues, which were first synthesized during an exercise in stereoselective π-complex chemistry, exhibited pronounced cytotoxic and apoptosis-inducing activities, even against resistant cancer cell lines. Both hetero- (X=O) and carbocyclic (X=CH2) compounds were studied, and a synthetic route to R′-labeled derivatives was developed as a precondition for future biological experiments. TDS=thexyldimethylsilyl. Copyright

Hybrid assemblies based on a gadolinium-containing polyoxometalate and a cationic polymer with spermine side chains for enhanced mri contrast agents

Chai, Wenqiang,Wang, Shan,Zhao, Hang,Liu, Guifeng,Fischer, Karl,Li, Haolong,Wu, Lixin,Schmidt, Manfred

supporting information, p. 13317 - 13321 (2013/10/08)

Supramolecular assembly: Spherical and stable hybrid assemblies based on a cationic polymer with spermine side chains and an anionic Gd3+- containing polyoxometalate cluster (GdW) are prepared by electrostatic interaction (see figure). The T1-weighted MRI performance of GdW is enhanced about three times in the assemblies; meanwhile, the assemblies show good biocompatibility, which enables them to be promising candidates for MRI contrast agents. Copyright

Iridium-catalyzed dehydrogenative decarbonylation of primary alcohols with the liberation of syngas

Olsen, Esben P. K.,Madsen, Robert

supporting information, p. 16023 - 16029 (2013/02/22)

A new iridium-catalyzed reaction in which molecular hydrogen and carbon monoxide are cleaved from primary alcohols in the absence of any stoichiometric additives has been developed. The dehydrogenative decarbonylation was achieved with a catalyst generated in situ from [Ir(coe)2Cl]2 (coe=cyclooctene) and racemic 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (rac-BINAP) in a mesitylene solution saturated with water. A catalytic amount of lithium chloride was also added to improve the catalyst turnover. The reaction has been applied to a variety of primary alcohols and gives rise to products in good to excellent yields. Ethers, esters, imides, and aryl halides are stable under the reaction conditions, whereas olefins are partially saturated. The reaction is believed to proceed by two consecutive organometallic transformations that are catalyzed by the same iridium(I)-BINAP species. First, dehydrogenation of the primary alcohol to the corresponding aldehyde takes place, which is then followed by decarbonylation to the product with one less carbon atom.

A surface-confined O=MnV(salen) oxene catalyst and high turnover values in asymmetric epoxidation of unfunctionalized olefins

La Paglia Fragola, Valentina,Lupo, Fabio,Pappalardo, Andrea,Trusso Sfrazzetto, Giuseppe,Toscano, Rosa M.,Ballistreri, Francesco P.,Tomaselli, Gaetano A.,Gulino, Antonino

supporting information, p. 20561 - 20565 (2013/02/23)

Given the widespread importance of chiral epoxides in chemical, biochemical and agricultural fields, an efficient synthesis that avoids wasteful use of the catalyst and assures its total recovery and reuse and high turnover values is highly desirable. We report on a thermally and temporally robust covalent monolayer of (salen)Mn(iii) molecules on silica functionalized substrates that resulted in an active heterogeneous catalyst for enantioselective epoxidation of 6-ciano-2,2-dimethyl-chromene, chosen as a model alkene, in high yields and high turnover numbers. No catalyst leaching was observed thus allowing continuous recycling. Experimental XPS evidence for the formation of the surface confined O=MnV(salen) oxene species has been obtained.

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