639780-60-2Relevant academic research and scientific papers
Synthesis of new 1,3,8-trisubstituted purine-2,6-diones and 1,3,6-trisubstituted thiazolo[2,3-f]purine-2,4diones
Hayallah, Alaa M.,Famulok, Michael
, p. 369 - 382 (2008/09/17)
New 1,3,8-trisubstituted purine-2,6-diones and 1,3,6-trisubstituted thiazolo[2,3-f]purine-2,4-diones were designed and synthesized as agents with potential biological activities. The final products were obtained by cyclization of carboxamide intermediates
SULFONAMIDE SUBSTITUTED XANTHINE DERIVATIVES FOR USE AS PEPCK INHIBITORS
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Page 35-36, (2010/02/08)
The present invention is concerned with sulfonamide substituted xanthine derivatives of formula (I) or a pharmaceutically acceptable salts or prodrugs thereof, wherein R1, R2 and R3 are as defined in the specification. Compounds of formula (I) and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.
X-ray structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines
Foley, Louise H.,Wang, Ping,Dunten, Pete,Ramsey, Gwendolyn,Gubler, Mary-Lou,Wertheimer, Stanley J.
, p. 3871 - 3874 (2007/10/03)
The analysis of the X-ray structures of two xanthine inhibitors bound to PEPCK and a comparison to the X-ray structure of GTP bound to PEPCK are reported. The SAR at N-1, N-7 and developing SAR at C-8 are consistent with information gained from the X-ray
