639780-60-2

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione,6-amino-3-[(2-fluorophenyl)methyl]-
• Synonyms: 6-Amino-3-(2-fluorobenzyl)-1H-pyrimidine-2,4-dione
• CAS NO: 639780-60-2
• Molecular Formula: C11H10 F N3 O2
• Molecular Weight: 235.218
• Mol File: 639780-60-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione,6-amino-3-[(2-fluorophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione,6-amino-3-[(2-fluorophenyl)methyl]-(639780-60-2)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione,6-amino-3-[(2-fluorophenyl)methyl]-(639780-60-2)

Safety Data

• Hazardous Substances Data: 639780-60-2(Hazardous Substances Data)

Usage

Structure

A derivative of pyrimidinedione with an amino group and a fluorophenylmethyl group.

Importance in medicinal chemistry

The presence of the amino group and fluorophenylmethyl group make it important for the synthesis of new drugs with therapeutic properties.

Potential applications

Pharmaceutical research, development of new materials, chemical synthesis processes, and further research and exploration of its potential biological activities and applications.

Upstream product

• 446-48-0 o-fluorobenzyl bromide 
• 873-83-6 6-amino-2,4-dihydroxypyrimidine 
• 873-83-6 4-Amino-2,6-dihydroxypyrimidine 

Downstream Products

• 748148-85-8 6-amino-3-(2-fluorobenzyl)-5-nitroso-1H-pyrimidine-2,4-dione 
• 639780-61-3 5,6-diamino-3-(2-fluoro-benzyl)-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Synthesis of new 1,3,8-trisubstituted purine-2,6-diones and 1,3,6-trisubstituted thiazolo[2,3-f]purine-2,4diones

New 1,3,8-trisubstituted purine-2,6-diones and 1,3,6-trisubstituted thiazolo[2,3-f]purine-2,4-diones were designed and synthesized as agents with potential biological activities. The final products were obtained by cyclization of carboxamide intermediates

X-ray structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines

The analysis of the X-ray structures of two xanthine inhibitors bound to PEPCK and a comparison to the X-ray structure of GTP bound to PEPCK are reported. The SAR at N-1, N-7 and developing SAR at C-8 are consistent with information gained from the X-ray