6398-98-7 Usage
Uses
Used in Pharmaceutical Industry:
Amodiaquin dihydrochloride dihydrate is used as an anti-malarial drug for treating malaria caused by Plasmodium species. It is effective in inhibiting the growth and development of the parasite, providing relief from the symptoms and complications associated with the disease.
Used in Research Applications:
Amodiaquin dihydrochloride dihydrate is used as a research compound for studying the mechanisms of action of anti-malarial drugs and the histamine N-methyltransferase enzyme. This helps in understanding the drug's mode of action and its potential for further development and improvement.
Used in Drug Development:
Amodiaquin dihydrochloride dihydrate is used as a starting material or a reference compound in the development of new anti-malarial drugs. Its chemical properties and known effects on the histamine N-methyltransferase enzyme make it a valuable tool for researchers working on novel therapeutic strategies against malaria.
Biological Activity
Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.
in vivo
In vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs. Amodiaquine prevents severe hepatic injury and high lethality in P. acnes-primed and LPS-induced hepatitis mice. Its treatment enhances the elevation of histamine in the liver of P. acnes-primed and LPS-induced hepatitis mice without accompanying tele-methyl histamine elevation.
Check Digit Verification of cas no
The CAS Registry Mumber 6398-98-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,9 and 8 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6398-98:
(6*6)+(5*3)+(4*9)+(3*8)+(2*9)+(1*8)=137
137 % 10 = 7
So 6398-98-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H22ClN3O.2ClH/c1-3-24(4-2)13-14-5-7-16(12-20(14)25)23-18-9-10-22-19-11-15(21)6-8-17(18)19;;/h5-12,25H,3-4,13H2,1-2H3,(H,22,23);2*1H
