6398-98-7 Usage
Chemical Properties
Light yellow powder
Uses
Different sources of media describe the Uses of 6398-98-7 differently. You can refer to the following data:
1. An anti-malarial quinoline derivative that acts as an histamine N-methyltransferase inhibitor
2. antimalarial
Biological Activity
Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.
in vivo
In vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs. Amodiaquine prevents severe hepatic injury and high lethality in P. acnes-primed and LPS-induced hepatitis mice. Its treatment enhances the elevation of histamine in the liver of P. acnes-primed and LPS-induced hepatitis mice without accompanying tele-methyl histamine elevation.
Check Digit Verification of cas no
The CAS Registry Mumber 6398-98-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,9 and 8 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6398-98:
(6*6)+(5*3)+(4*9)+(3*8)+(2*9)+(1*8)=137
137 % 10 = 7
So 6398-98-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H22ClN3O.2ClH/c1-3-24(4-2)13-14-5-7-16(12-20(14)25)23-18-9-10-22-19-11-15(21)6-8-17(18)19;;/h5-12,25H,3-4,13H2,1-2H3,(H,22,23);2*1H
