63980-44-9

Basic information

• Product Name: 1,4-bis(2-chloroethyl)piperazine hydrochloride (1:1)
• CAS NO: 63980-44-9
• Molecular Formula: C₈H₁₆Cl₂N₂*2ClH
• Molecular Weight: 247.593
• Mol File: 63980-44-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 288.4°C at 760 mmHg
• Flash Point: 128.2°C
• Vapor Pressure: 0.00234mmHg at 25°C
• CAS DataBase Reference: 1,4-bis(2-chloroethyl)piperazine hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-bis(2-chloroethyl)piperazine hydrochloride (1:1)(63980-44-9)
• EPA Substance Registry System: 1,4-bis(2-chloroethyl)piperazine hydrochloride (1:1)(63980-44-9)

Safety Data

• Hazardous Substances Data: 63980-44-9(Hazardous Substances Data)

Usage

Composition

Molecule of 1,4-bis(2-chloroethyl)piperazine combined with one molecule of hydrochloric acid

Classification

Alkylating agent

Function

Binds to and damages DNA, disrupting cell function and potentially causing cell death

Application

Used in the past as a component of chemotherapy drugs for the treatment of certain types of cancer

Current Use

Use has decreased due to toxic effects and potential for causing harm to healthy tissue

Hazardous Classification

Classified as a hazardous chemical

Handling Precaution

Should be handled and used with caution due to potential harm to humans and the environment

Upstream product

• 122-96-3 1,4-bis(2-hydroxyethyl)piperazine 
• 15567-82-5 1,4-bis(2'-chloroethyl)-1,4-diazabicyclo-<2.2.1>heptane dichloride 

Downstream Products

• 109495-32-1 1,4-bis-(2-trimethylammonio-ethyl)-piperazine; diiodide 
• 116810-30-1 4-methyl-2-phenyl-pentanoic acid 2,2'-piperazine-1,4-diyl-diethyl ester 
• 114909-63-6 2-(4-chloro-phenyl)-butyric acid 2,2'-piperazine-1,4-diyl-diethyl ester 
• 10586-98-8 1,4-bis-(2-dimethylamino-ethyl)-piperazine 
• 116032-02-1 2-phenyl-hexanoic acid 2,2'-piperazine-1,4-diyl-diethyl ester 
• 7077-33-0 1.4-Bis-<2-(2-phenyl-butyryl-oxy)-ethyl>-piperazin 
• 22746-11-8 1,4-bis<2-(1-piperidino)ethyl>piperazine 

Relevant articles and documents

Amine ethylated piperazine and preparation method thereof

The invention provides a preparation method of an amine ethylated piperazine, and relates to the technical field of preparation of aminoethyl piperazine. The method comprises the following steps: mixing a piperazine compound, a chlorination reagent and a soluble piperazine compound solvent to carry out chlorination reaction to obtain the chloropiperazine hydrochloride. The piperazine compound comprises 2 - hydroxyethyl piperazine or N, N' - bis (2 - hydroxyethyl) piperazine. The chloropiperazine hydrochloride, the organic amine and the water are mixed, and the substitution reaction is carried out to obtain the aminated piperazine. The organic amine includes methylamine. Diethylamine, propylamine. The preparation method provided by the invention is high in product yield, high in purity, simple to operate, wide in reaction raw material source, low in production cost and suitable for industrial production.

STABILITY OF THE 1,4-BIS(2'-HALOETHYL)-1,4-DIAZABICYCLOYHEPTANE DICATION

Certain derivatives of the 1,4-bis(2'-haloethyl-1,4-diazabicycloheptane dication system ranging from dibromide 2b to ethanesulfonate 2g were found to be quite stable under essentially neutral conditions.A very convenient synthesis of 1,4-bis(2'-chl