6399-81-1

Basic information

• Product Name: Triphenylphosphine hydrobromide
• Synonyms: TPH;TRIPHENYLPHOSPHINE HYDROBROMIDE;TRIPHENYLPHOSPHONIUM BROMIDE;Triphenylphosphoniumbromide,99.9%;Phosphine, triphenyl-, hydrobromide;Triphenylphosphine hydrobromide 97%;Phosphine, triphenyl-, compd. with hydrobromic acid;Triphenylphosphonium bromide,99%
• CAS NO: 6399-81-1
• Molecular Formula: Br*C₁₈H₁₆P
• Molecular Weight: 343.2
• EINECS: 229-012-6
• Mol File: 6399-81-1.mol
• Article Data: 27

Chemical Properties

• Melting Point: 196 °C (dec.)(lit.)
• Boiling Point: 360 °C at 760 mmHg
• Flash Point: 181.7 °C
• Appearance: White to light beige/Crystalline Powder or Chunks
• Storage Temp.: -20°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Water Solubility: Soluble in water.
• BRN: 3633387
• CAS DataBase Reference: Triphenylphosphine hydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: Triphenylphosphine hydrobromide(6399-81-1)
• EPA Substance Registry System: Triphenylphosphine hydrobromide(6399-81-1)

Safety Data

• Hazard Codes: C,Xi
• Statements: 22-34-36/37/38
• Safety Statements: 26-36/37/39-45-36
• RIDADR: UN 3261 8/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 6399-81-1(Hazardous Substances Data)

Usage

Chemical Properties

white to light beige crystalline powder or chunks

Uses

Different sources of media describe the Uses of 6399-81-1 differently. You can refer to the following data:
1. Triphenylphosphine hydrobromide is the hydrobromide salt of Triphenylphosphine, used in the preparation of uridine derivatives as substrate donor analogs of UDP-sugars for glycosyltransferases. Also used in the preparation of tensioactive and antibacterial deoxyglycoside compounds via catalysis.
2. Triphenylphosphine hydrobromide is used as mild source of anhydrous HBr; catalyst for formation of THP ethers from tertiary alcohols; preparation of phosphonium salts.

InChI:InChI=1/C18H15P.BrH/c1-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18;/h1-15H;1H

Upstream product

• 21851-76-3 (indan-1-yl)triphenylphosphonium bromide 
• 3968-92-1 (1-methylethyl)triphenylphosphonium bromide 
• 603-35-0 triphenylphosphine 
• 507-19-7 t-butyl bromide 

Downstream Products

• 856952-48-2 geranyltriphenylphosphphonium bromide 
• 1530-34-3 (3-methylbut-2-enyl)triphenylphosphonium bromide 
• 6228-47-3 n-propyltriphenylphosphonium bromide 
• 2175-67-9 (7-methoxy-3,7-dimethyl-oct-2-enyl)-triphenyl-phosphonium; bromide 
• 51276-36-9 (6-Acetoxy-3,7-dimethylocta-2,7-dien-1-yl)-triphenylphosphiniumbromid 
• 73367-76-7 4-Diphenylphosphinoylbutanoic acid 
• 78133-84-3 (2-aminobenzyl)triphenylphosphonium bromide 
• 78173-51-0 2-triphenylphosphoranylidene-3-methylsuccinic acid diethyl ester 
• 1779-51-7 n-butyl(triphenyl)phosphonium bromide 
• 59060-56-9 triphenyl-((2E,4E,6E)-3,7,11-trimethyl-dodeca-2,4,6,10-tetraenyl)-phosphonium; bromide 
• 89266-26-2 [1-(2-hydroxyphenyl)ethyl]triphenylphosphonium bromide 
• 50889-29-7 (5-carboxypentyl)triphenylphosphonium bromide 

Relevant articles and documents

A convenient and economic way to produce anhydrous hydrogen bromide

Bromide promoted decomposition of tert-butyl bromide in the presence of triphenylphosphine gives, besides isobutene, hydrogen(triphenyl)phosphonium bromide. When heated to approximately 150°C in the presence of xylene, the latter salt liberates hydrogen bromide which may then be trapped in an aprotic solvent such as diethyl ether.

Simplified Structural Mimetics of AIPS as Quorum Sensing Inhibitors

Compounds that regulate quorum sensing in Staphylococcal bacteria and in particular in Staphylococcus aureus are provided. Compounds are described in formulas I, II, III, IV, V and VI herein. One or more compounds herein can be employed to inhibit QS and to thus inhibit virulence in Staphylococcus bacteria and in particular in Staphylococcus aureus. Compounds herein and pharmaceutical compositions containing one or more of these compounds are useful, for example, in treating infections of Staphylococcus bacteria and in particular of Staphylococcus aureus. Methods for treating such bacterial infections are provided.

Enantioselective Trifluoromethylthiolating Lactonization Catalyzed by an Indane-Based Chiral Sulfide

Enantioselective trifluoromethylthiolation, especially of alkenes, is a challenging task. In this work, we have developed an efficient approach for enantioselective trifluoromethylthiolating lactonization by designing an indane-based bifunctional chiral sulfide catalyst and a shelf-stable electrophilic SCF3 reagent. The desired products were formed with diastereoselectivities of >99:1 and good to excellent enantioselectivities. The transformation represents the first enantioselective trifluoromethylthiolation of alkenes and the first enantioselective trifluoromethylthiolation that is enabled by a catalyst with a Lewis basic sulfur center.