63991-14-0

Usage

General Description

1-(2,4-dimethoxyphenyl)-1-hydroxypropan-2-aminium chloride, also known as 5-hydroxytryptamine, is a chemical compound that acts as a neurotransmitter and hormone in the body. It is a derivative of serotonin, a neurotransmitter responsible for regulating mood, appetite, and sleep. 1-(2,4-dimethoxyphenyl)-1-hydroxypropan-2-aminium chloride plays a crucial role in mediating the physiological and behavioral responses related to stress, anxiety, and depression. It also acts as a vasoconstrictor and functions in the regulation of gastrointestinal motility. Additionally, it is widely used in pharmaceuticals and research as it is involved in the pathophysiology of various medical conditions, and its analogs are used as drugs for psychiatric disorders and migraine headaches.

Upstream product

• 72739-16-3 2-amino-1-(2,4-dimethoxy-phenyl)-propan-1-one; hydrochloride 

Downstream Products

• 33189-36-5 (+/-)-2,4-Dimethoxyamphetamine hydrochloride 
• 83657-22-1 uniconazole 

Relevant academic research and scientific papers

Asymmetrically modified boron hydride type compound, a production method thereof, and a method for producing an optically active alcohol derivative by the use thereof

The present invention relates to an asymmetrically modified borohydride type compound obtained by reacting an optically active amino alcohol represented by the formula, STR1 or its salt with an acid with a borohydride compound; its production method; and a method for producing an optically active alcohol derivative useful as fungicides, herbicides or plant growth regulators and represented by the formula, STR2 which comprises asymmetrically reducing a ketone compound represented by the formula, STR3 with the asymmetrically modified borohydride type compound.

Serotonin receptor affinities of psychoactive phenalkylamine analogues

Employing a rat fundus model, the serotonin (5-HT) receptor affinities of 45 phenalkylamine analogues were determined. Phenethylamine and phenylisopropylamine possess relatively low receptor affinities; in general, mono-, di-, and trimethoxylation enhance affinity. Of the disubstituted compounds, methoxyl groups at the 2 and 5 positions are optimal for imparting a high affinity. 4-Methylation, 4-ethylation and 4-bromination also enhance receptor affinity, while N,N-dimethylation of the terminal amine decreases affinity. α-Methylation of phenethylamines has little effect on affinity when racemates are examined. Introduction of a benzylic keto group can either increase or decrease affinity, depending upon the presence of other aromatic substituents. The most behaviorally active compounds were found to possess the highest 5-HT receptor affinities, while less active compounds were found to possess lower affinities.