64003-81-2Relevant academic research and scientific papers
Syntheses, antiproliferative activity and theoretical characterization of acitretin-type retinoids with changes in the lipophilic part
Magoulas, George E.,Bariamis, Stavros E.,Athanassopoulos, Constantinos M.,Haskopoulos, Anastasios,Dedes, Petros G.,Krokidis, Marios G.,Karamanos, Nikos K.,Kletsas, Dimitris,Papaioannou, Dionissios,Maroulis, George
, p. 721 - 737 (2011/03/20)
Acitretin analogs, incorporating changes in the lipophilic part, were efficiently synthesized from commercially available aromatic aldehydes or methyl ketones using the Wittig or Horner-Wadsworth-Emmons reaction. Their antiproliferative activity was evaluated against human breast MCF-7 epithelial cells. Analogs 3, 4, 8 and 11 exhibited strong, dose-dependent, antiproliferative activity on the tested cell line. Analog 3, incorporating three methoxy groups in the aromatic ring, exhibited the strongest inhibitory effect at 10 μM. High-level all electron conventional ab initio and density functional theory quantum chemical calculations were performed to obtain the molecular structure, electron charge distribution and polarization properties of all compounds of interest in this work. The most active analogs were planar and were characterized by larger dipole moments than the other synthesized molecules. Another factor of importance to the analysis of the activity of these molecules is the dipole polarizability.
Photocurrents of solar cells sensitized by aggregate-forming polyenes: Enhancement due to suppression of singlet-triplet annihilation by lowering of dye concentration or light intensity
Wang, Xiao-Feng,Koyama, Yasushi,Nagae, Hiroyoshi,Yamano, Yumiko,Ito, Masayoshi,Wada, Yuji
, p. 309 - 315 (2008/02/12)
Titania-based Gr?tzel-type solar cells were fabricated by the use of polyene dyes with various transition dipole moments. In the dye having the largest transition dipole among the samples, an aggregate was readily formed through dispersive interaction, an
