64005-91-0Relevant academic research and scientific papers
Analgesic activity of cyclic imides: 1,8-Naphthalimide and 1,4,5,8- naphthalenediimide derivatives
Andricopulo, Adriano Defini,Mueller, Luciane A.,Cechinel Filho, Valdir,Cani, Graziela S.,Roos, Juliana F.,Correa, Rogerio,Santos, Adair Roberto S.,Nunes, Ricardo Jose,Yunes, Rosendo Augusto
, p. 319 - 321 (2007/10/03)
In early studies, we have reported the synthesis and biological activities of several cyclic imides. The present study describes the analgesic activity of 1,8-naphthalimide and 1,4,5,8-naphthalenediimide derivatives in a standard murine model of analgesia. The pharmacological results show that all compounds studied, given intraperitoneally, produced significant inhibition of acetic acid-induced abdominal constrictions. At the ID50 (μmol/kg) level, these cyclic imide derivatives were about 40-270- fold more potent in this assay than aspirin and acetaminophen, two well-known and widely used analgesics. These results extend previous studies on the analgesic activity of cyclic imides. (C) 2000 Elsevier Science S.A.
