64018-41-3Relevant academic research and scientific papers
Cycloaddition/ring opening sequence of α-hydroxy cyclic nitronates as a synthetic equivalent of functionalized aliphatic nitrile oxides
Nishiuchi, Masaki,Sato, Hiroyasu,Ohmura, Hiroyuki
, p. 144 - 145 (2008)
α-Hydroxy cyclic nitronates act as synthetic equivalents of nitrile oxides. Cycloaddition of 3-substituted 4-hydroxy-2-isoxazoline N-oxides or 4-hydroxy-3-hydroxymethyl-2-isoxazoline N-oxides with electron-deficient alkenes produce bicyclic isoxazolidines
Synthesis and evaluation of 4,5-dihydro-5-methylisoxazolin-5-carboxamide derivatives as VLA-4 antagonists
Soni, Ajay,Rehman, Abdul,Naik, Keshav,Dastidar, Sunanda,Alam,Ray, Abhijit,Chaira, Tridib,Shah, Vanya,Palle, Venkata P.,Cliffe, Ian A.,Sattigeri, Viswajanani J.
, p. 1482 - 1485 (2013/03/14)
A novel set of compounds containing a 4,5-dihydro-5-methylisoxazoline have been successfully designed as VLA-4 receptor antagonists. Compound (14p) had a high receptor binding affinity of 4 nM and also found to be metabolically stable in vitro.
HETEROCYCLIC DERIVATIVES AS CELL ADHESION INHIBITORS
-
Page/Page column 39, (2008/06/13)
The present invention relates to certain heterocyclic derivatives of formula (I) , in particular isoxazoline and isothiazoline derivatives as cell adhesion inhibitors. The compounds of this invention can be useful, for inhibition and prevention of cell ad
Synthesis of some isoxazolines and evaluation of carbon-13 NMR substituent parameters for 5-methyl substitution
Nagarajan, A.,Pillay, M. Krishna
, p. 938 - 941 (2007/10/02)
Some isoxazolines substituted at C-5 with phenyl and methoxycarbonyl groups have been synthesised and characterised.Carbon-13 NMR methyl substituent parameters for methyl substitution at C-5 carbon in these compounds have been evaluated.
