640270-58-2

Upstream product

• 377751-03-6 (3S,4R,6E)-1,1-dibromo-8-(tert-butyldiphenylsilyloxy)-3-[(4-methoxyphenyl)methoxy]-4-methyl-1,6-octadiene 
• 377751-10-5 (2S,3R,5E)-7-(tert-butyldiphenylsilyloxy)-2-[(4-methoxyphenyl)methoxy]-3-methyl-5-hepten-1-ol 
• 377751-09-2 (2E,5R,6S)-6-[(4-methoxyphenyl)methoxy]-5-methyl-2-heptene-1,7-diol 
• 377751-19-4 (E)-(R)-5-[(S)-2-(4-Methoxy-phenyl)-[1,3]dioxolan-4-yl]-hex-2-en-1-ol 
• 377751-06-9 ethyl (2E,5R,6S)-6,7-(isopropylidene)dioxy-5-methyl-2-heptenoate 
• 377751-07-0 (2E,5R,6S)-6,7-(isopropylidene)dioxy-5-methyl-2-hepten-1-ol 
• 377751-08-1 (2S,3R,5E)-3-methyl-5-heptene-1,2,7-triol 

Downstream Products

• 640270-56-0 (1Z,3S,4R,6E)-8-(tert-butyldiphenylsilyloxy)-3-[(4-methoxyphenyl)methoxy]-4-methyl-1-tributylstannyl-1,6-octadiene 

Relevant academic research and scientific papers

Total synthesis of macquarimicins using an intramolecular Diels-Alder approach inspired by a biosynthetic pathway

A total synthesis of the macquarimicins A-C (1-3), novel natural products with intriguing tetra- or pentacyclic frameworks, has been achieved. The synthesis features an extensive investigation of the biosynthesis-based intramolecular Diels-Alder (IMDA) re

Total Synthesis of (+)-Macquarimicin A

The first total synthesis of (+)-macquarimicin A (1), a novel inhibitor of neutral sphingomyelinase (N-SMase) with antiinflammatory activity, has been accomplished. The present work determined the absolute configuration of (+)-1 and revised the C(2)?C(3)