640270-63-9

Upstream product

• 640270-59-3 (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}hex-5-ynal 
• 640270-65-1 (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}hex-5-ynenitrile 
• 640270-68-4 (2R,4R)-1-(2,2-dimethyl-1,3-dioxin-4-one-6-yl)-6-heptyne-2,4-diol 
• 640270-60-6 (4R)-1-(2,2-dimethyl-1,3-dioxin-4-one-6-yl)-4-hydroxy-6-heptyn-2-one 
• 640270-67-3 (4R)-4-(tert-butyldimethylsilyloxy)-1-(2,2-dimethyl-1,3-dioxin-4-one-6-yl)-6-heptyn-2-one 
• 640270-66-2 (2RS,4R)-4-(tert-butyldimethylsilyloxy)-1-(2,2-dimethyl-1,3-dioxin-4-one-6-yl)-6-heptyn-2-ol 
• 640270-69-5 (2R,4R)-2,4-bis(tert-butyldimethylsilyloxy)-1-(2,2-dimethyl-1,3-dioxin-4-one-6-yl)-6-heptyne 
• 640270-57-1 (2R,4R,6E)-2,4-bis(tert-butyldimethylsilyloxy)-1-(2,2-dimethyl-1,3-dioxin-4-one-6-yl)-7-iodo-6-heptene 
• 640270-61-7 (2R,4R)-7-bromo-2,4-bis(tert-butyldimethylsilyloxy)-1-(2,2-dimethyl-1,3-dioxin-4-one-6-yl)-6-heptyne 
• 640270-62-8 (2E,5R,6S,7Z,9E,12R,14R)-12,14-bis(tert-butyldimethylsilyloxy)-15-(2,2-dimethyl-1,3-dioxin-4-one-6-yl)-6-[(4-methoxyphenyl)methoxy]-5-methyl-2,7,9-pentadecatrien-1-ol 
• 640270-71-9 (2E,5R,6S,7Z,9E,12R,14R)-12,14-bis(tert-butyldimethylsilyloxy)-15-(2,2-dimethyl-1,3-dioxin-4-one-6-yl)-1-(methoxycarbonyl)oxy-6-[(4-methoxyphenyl)methoxy]-5-methyl-2,7,9-pentadecatriene 
• 640270-70-8 (2E,5R,6S,7Z,9E,12R,14R)-12,14-bis(tert-butyldimethylsilyloxy)-1-(tert-butyldiphenylsilyloxy)-15-(2,2-dimethyl-1,3-dioxin-4-one-6-yl)-6-[(4-methoxyphenyl)methoxy]-5-methyl-2,7,9-pentadecatriene 
• 182681-88-5 (2R)-1-cyano-2-hydroxy-4-pentyne 
• 640270-55-9 methyl (5R,7R,9E,11Z,13S,14R,16E)-5,7-bis(tert-butyldimethylsilyloxy)-18-(methoxycarbonyl)oxy-13-[(4-methoxyphenyl)methoxy]-14-methyl-3-oxo-9,11,16-octadecatriene-1-carboxylate 

Downstream Products

• 773104-59-9 (2Z,4E,7R,8S,9Z,11E,14R,16R)-14,16-bis(tert-butyldimethylsilyloxy)-2-methoxycarbonyl-8-[(4-methoxyphenyl)methoxy]-7-methyl-2,4,9,11-cycloheptadecatetraen-1-one 
• 773104-70-4 (E)-(2R,3S,3aS,5aS,7R,9R,13aS,13bR)-7,9-Bis-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2-methyl-11-oxo-2,3,3a,5a,6,7,8,9,10,11,13a,13b-dodecahydro-1H-cyclodeca[e]indene-12-carboxylic acid methyl ester 
• 640270-74-2 (1RS,3E,6R,7S,8Z,10E,13R,15R)-13-hydroxy-7-[(4-methoxyphenyl)methoxy]-6-methyl-1-phenylselenyl-16-oxabicyclo[13.2.2]nonadeca-3,8,10-triene-17,18-dione 
• 640270-73-1 (1RS,3E,6R,7S,8Z,10E,13R,15R)-13-hydroxy-7-[(4-methoxyphenyl)methoxy]-6-methyl-16-oxabicyclo[13.2.2]nonadeca-3,8,10-triene-17,18-dione 
• 640270-54-8 (1EZ,3E,6R,7S,8Z,10E,13R,15R)-13-hydroxy-7-[(4-methoxyphenyl)methoxy]-6-methyl-16-oxabicyclo[13.2.2]nonadeca-1,3,8,10-17,18-dione 
• 773104-85-1 (3E,8Z,10E)-(6R,7S,13R,15R)-13,15-Bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-6-methyl-17-oxo-1-phenylselanyl-cycloheptadeca-3,8,10-trienecarboxylic acid methyl ester 
• 640270-72-0 (2RS,4E,7R,8S,9Z,11E,14R,16R)-14,16-dihydroxy-2-methoxycarbonyl-8-[(4-methoxyphenyl)methoxy]-7-methyl-4,9,11-cycloheptadecatrien-1-one 

Relevant academic research and scientific papers

Total synthesis of macquarimicins using an intramolecular Diels-Alder approach inspired by a biosynthetic pathway

A total synthesis of the macquarimicins A-C (1-3), novel natural products with intriguing tetra- or pentacyclic frameworks, has been achieved. The synthesis features an extensive investigation of the biosynthesis-based intramolecular Diels-Alder (IMDA) re

Total Synthesis of (+)-Macquarimicin A

The first total synthesis of (+)-macquarimicin A (1), a novel inhibitor of neutral sphingomyelinase (N-SMase) with antiinflammatory activity, has been accomplished. The present work determined the absolute configuration of (+)-1 and revised the C(2)?C(3)