640296-20-4Relevant academic research and scientific papers
A new class of glycogen phosphorylase inhibitors
Lu, Zhijian,Bohn, Joann,Bergeron, Raynald,Deng, Qiaolin,Ellsworth, Kenneth P.,Geissler, Wayne M.,Harris, Georgianna,McCann, Peggy E.,McKeever, Brian,Myers, Robert W.,Saperstein, Richard,Willoughby, Christopher A.,Yao, Jun,Chapman, Kevin
, p. 4125 - 4128 (2007/10/03)
A new class of diacid analogues that binds at the AMP site not only are very potent but have ～10-fold selectivity in liver versus muscle glycogen phosphorylase (GP) in the in vitro assay. The synthesis, structure, and in vitro and in vivo biological evaluation of these liver selective glycogen phosphorylase inhibitors are discussed.
