64037-22-5

Basic information

• Product Name: 5-CHLOROBENZOXAZOL-2-YL-HYDRAZINE
• Synonyms: 5-CHLOROBENZOXAZOL-2-YL-HYDRAZINE;5-chloro-2-hydrazinylBenzoxazole;(5-chloro-1,3-benzoxazol-2-yl)hydrazine
• CAS NO: 64037-22-5
• Molecular Formula: C₇H₆ClN₃O
• Molecular Weight: 183.6
• Mol File: 64037-22-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 334.7°Cat760mmHg
• Flash Point: 156.2°C
• Appearance: /
• Density: 1.553g/cm³
• Vapor Pressure: 0.000126mmHg at 25°C
• Refractive Index: 1.745
• CAS DataBase Reference: 5-CHLOROBENZOXAZOL-2-YL-HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLOROBENZOXAZOL-2-YL-HYDRAZINE(64037-22-5)
• EPA Substance Registry System: 5-CHLOROBENZOXAZOL-2-YL-HYDRAZINE(64037-22-5)

Safety Data

• Hazardous Substances Data: 64037-22-5(Hazardous Substances Data)

Usage

General Description

5-Chlorobenzoxazol-2-yl-hydrazine is a chemical compound with a molecular formula C7H6ClN3O. It is a potential intermediate in the production of pharmaceuticals and agrochemicals. 5-CHLOROBENZOXAZOL-2-YL-HYDRAZINE is a hydrazine derivative and contains a benzoxazol ring with a chlorine substituent. It has applications in the synthesis of various organic compounds due to its reactivity as a nucleophile. Additionally, it possesses potential biological activities that make it a subject of interest in medicinal and agricultural research.

InChI:InChI=1/C7H6ClN3O/c8-4-1-2-6-5(3-4)10-7(11-9)12-6/h1-3H,9H2,(H,10,11)

Upstream product

• 95-85-2 2-hydroxy-5-chloro-aniline 
• 3621-81-6 2,5-dichloro-1,3-benzoxazole 
• 22876-19-3 5-chloro-2-mercaptobenzoxazole 

Relevant articles and documents

Studies on novel rearangement of benzoxazolethiol

A new chemoselective approach to synthesize a series of benzoimidazole 2a-c, 3, 4a, b and benzoxazol-2-thiol derivatives 5a-c, 6, 7a,b. Benzoxazol-2-thiol derivatives under action of N-nucleophiles, by using this methodology, two series of heterocyclic systems were synthesized. 7-Chloro-2-methyl/or aryl-benzo-[4,5]imidazo[1,2,4] thiadiazole derivatives 8,9 and 10a-c were prepared via cyclocondensation and condensation elimination reaction.

3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives: Inhibitors of immune complex induced inflammation

3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives were evaluated in the dermal and pleural reverse passive Arthus reactions in the rat. In the pleural test these compounds were effective in reducing exudate volume and accumulation of white blood cells. This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin. The structural requirements for inhibiting the Arthus reactions were studied by systematic chemical modification of 1. These structure-activity relationship studies revealed that nitrogen 1' of the hydrazino group is essential for activity and must be electron rich, whereas chemical modifications of other sites of 1 had only a modest effect on activity.