64038-88-6

Basic information

• Product Name: 4-Morpholinobenzaldehyde thiosemicarbazone
• Synonyms: 4-Morpholinobenzaldehyde thiosemicarbazone
• CAS NO: 64038-88-6
• Molecular Formula: C12H16 N4 O S
• Molecular Weight: 0
• Mol File: 64038-88-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 461.889°C at 760 mmHg
• Flash Point: 233.142°C
• Appearance: /
• Density: 1.315g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.652
• CAS DataBase Reference: 4-Morpholinobenzaldehyde thiosemicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Morpholinobenzaldehyde thiosemicarbazone(64038-88-6)
• EPA Substance Registry System: 4-Morpholinobenzaldehyde thiosemicarbazone(64038-88-6)

Safety Data

• Hazardous Substances Data: 64038-88-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H16N4OS/c13-12(18)15-14-9-10-1-3-11(4-2-10)16-5-7-17-8-6-16/h1-4,9H,5-8H2,(H3,13,15,18)/b14-9+

Upstream product

• 1204-86-0 4-(4-morpholinyl)benzaldehyde 
• 79-19-6 thiosemicarbazide 
• 459-57-4 4-fluorobenzaldehyde 

Relevant articles and documents

Design, synthesis and biological assessment of new thiazolylhydrazine derivatives as selective and reversible hMAO-A inhibitors

In the recent works, it was shown that numerous thiazolylhydrazine derivatives display hMAO inhibitory activity in the range of micromolar concentration. Hence, in the present study a new series of new thiazole-hydrazines (3a-3n) were designed, synthesized, characterized and screened for their hMAO-A and hMAO-B inhibitory activity by an in vitro flurometric method. The enzyme inhibition assay revealed that most of the synthesized compounds have selective inhibition potency against hMAO-A. The compounds 3f and 3h showed promising hMAO-A inhibition with an IC50 values of 0.012 μM and 0.011 μM and significant selectivity indexes of 1214 and 1601 towards hMAO-A, respectively. The mechanism of hMAO-A inhibition of compounds 3f and 3h was investigated by Lineweaver-Burk graphics and reversible-competitive inhibition of hMAO-A was determined. Cytotoxicity and genotoxicity studies were carried out and the compound 3h was found as non-cytotoxic and non-genotoxic. Theoretical calculation of ADME properties suggested that synthesized compounds may have a good pharmacokinetic profile. The docking study of compound 3f and 3h revealed that there is a strong interaction between the active sites of hMAO-A and analyzed compound.