6404-76-8

Usage

Type

Synthetic organic compound

Properties

Antioxidant

Usage in food industry

Prevents rancidity in fats and oils

Usage in rubber and petroleum industry

Prevents oxidation and degradation

Usage in cosmetics and personal care products

Extends shelf life and stability

Regulatory status

Approved for use in food and cosmetic products by regulatory authorities

Safety concerns

Potential toxicity and carcinogenicity in high concentrations

Regulation

Use in consumer products is regulated to ensure safety for human consumption

InChI:InChI=1/C13H15NO2/c1-2-3-8-14-11-7-5-4-6-10(11)12(15)9-13(14)16/h4-7,9,16H,2-3,8H2,1H3

Upstream product

• 161185-27-9 6-butyl-3H-pyrano[3,2-c]quinoline-2,4,5(6H)-trione 
• 1126-78-9 N-(n-butyl)aniline 
• 161185-41-7 3-Acetyl-1-butyl-4-hydroxy-1H-quinolin-2-one 

Relevant academic research and scientific papers

Syntheses of 3-Acyl-4-hydroxy-2(1H)-quinolones

3-Acyl-4-hydroxy-2(1H)-quinolones 5 are obtained by hydrolytic ring opening and subsequent decarboxylation from the corresponding pyranoquinolin-2,5(6H)-diones 4, which in turn are easily obtained from 1:2 condensation of of anilines 1 with diethyl malonate 2a or 1:1 condensation of diethyl alkyl- or arylmalonates 2b-e with 4-hydroxy-2(1H)-quinolones 3.Nitropyranoquinolinediones 6 furnish after ringopening 3-nitroacetyl-4-hydroxy-2(1H)-quinolones 8.Pyranoquinolines 7 and 9 with acetyl- or aminosubstituents are hydrolyzed during basic ringopening to yield 5.

Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-carboxylic acid esters

Disclosed are compounds which are 4-hydroxy-2-quinolinone-3-carboxylic acid esters, e.g., 1-methyl-4-hydroxy-2-quinolinone-3-carboxylic acid ethyl ester, useful as anti-allergic agents and intermediates for 1-alkyl-4-alkoxy-quinolin-2(1H)-ones, and prepared by reacting an isatoic anhydride with an alkali metal salt of a malonic ester.