64048-12-0

Usage

Uses

Used in Organic Synthesis:
2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE is used as a key intermediate in the synthesis of complex organic molecules, particularly those with potential applications in pharmaceuticals, agrochemicals, and functional materials. Its unique structure allows for the formation of diverse molecular architectures through various chemical reactions.
Used in Materials Science:
In the field of materials science, 2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE is used as a building block for the development of novel materials with tailored electronic, optical, and structural properties. It can be incorporated into polymers, dendrimers, and other supramolecular structures to create materials with specific functions, such as organic semiconductors, light-emitting diodes, and sensors.
Used in Medicinal Chemistry:
2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE is used as a pharmacophore in the design and synthesis of new drugs targeting various biological pathways. Its modulatory ability on cell growth, differentiation, and activation makes it a promising candidate for the development of therapeutic agents against various diseases, including cancer and immune disorders.
Used in T Regulatory Cell Modulation:
2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE, specifically in the form of GANT58, is used as an inhibitor of GLI1-induced transcription in T regulatory cells. This modulatory ability is critical for maintaining self-tolerance, immune suppression, and tumor immunosurveillance. GANT58 also inhibits hedgehog signaling, inducing apoptosis in acute T cell leukemia cells, making it a potential therapeutic agent for cancer treatment.

Biological Activity

gant 58 is an antagonist of gli that inhibits gli1-induced transcription with an ic50 value of 5 μm [1].gli1 is a human glioblastoma isolated protein which belongs to gli protein family. gli proteins act as effectors in hedgehog signaling pathway and get involved in cell proliferation, determination and patterning during embryo development.gant 58 is considered to inhibit gli1-mediated gene trans-activation with a high selectivity for hedgehog signaling pathway. when tnf signaling/nfkb activation, glucocorticoid, receptor gene transactivation, and the ras-raf-mek-mapk cascade were treated with gant 58, no inhibition was observed. when sag-treated shh-l2 cells were treated with 10 μm gant 58 for 48 hr, the reduction of hedgehog pathway signaling was observed, whereas gli1 mrna level reduction was induced by the treatment of 10 μm gant 58 for 2-3 days. indeed, gant 58 was confirmed as inhibitor of hedgehog signaling pathway downstream sufu and smo [1]. furthermore, gant 58 treatments for 48 hr resulted in the significant reduction of cell viability in a dose-dependent manner for ccrfecem, cem7e14, cem1e15 and jurkat cells. when ccrfecem cells were treated with 10 μm gant 58 for 48 hr, the percentage of cells in g1/s phase increased whereas the percentage in g2/m phase decreased [2].in mouse model with xenograft, daily s.c. injection of gant 58 resulted in significant suppression of tumor cell growth. 50 mg/kg/d gant 58 injections for 18 days induced the suppression of additional xenograft growth and restrict the increase of tumor size. no side effects were observed during the treatment [1].

Upstream product

• 108-89-4 picoline 

Downstream Products

• 1042450-26-9 [Cd(tetra(4-pyridyl)thiophene)(1,3-benzenedicarboxylic acid-2H)]*1,3-benzenedicarboxylic acid 

Relevant academic research and scientific papers

ELEMENTAL SULFUR REACTIONS WITH 4-PICOLINE

A study of the reaction of the elemental sulfur with 4-picoline is reported.The process was carried out at the boiling point of the 4-picoline under argon.After removing unreacted solids, the reaction products were identified by means of LC, GC, and GC-MS