64064-19-3Relevant academic research and scientific papers
Benzodiazepine derivatives and pharmaceutical compositions containing said derivatives
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, (2008/06/13)
Novel 4H-pyrrolo[1,2-a][1,4]benzodiazepine derivatives of the formula STR1 wherein at least one of R1, R2 and R3 represent lower alkyl and the remainder hydrogen, R4 represents hydrogen or lower alkyl, ring A optionally contains at least one substituent selected from halogen, nitro and trifluoromethyl, and ring B optionally contains at least one substituent selected from halogen, nitro, trifluoromethyl, lower alkyl and lower alkoxy; and novel intermediates thereof expressed by the formula STR2 wherein Z represents protected amino. Compounds of formula (I) are prepared by subjecting compounds of formula (II) to protective group-elimination and cyclization. The compounds of formula (I) and acid addition salts thereof have useful anti-anxietic, sedative, anti-convulsant, muscle relaxant and hypnotic, and their toxicity is low.
