640714-45-0

Basic information

• Product Name: N-mesityl-2,3-dihydro-1,4-benzodioxine-6-sulfonamide
• Synonyms: N-mesityl-2,3-dihydro-1,4-benzodioxine-6-sulfonamide
• CAS NO: 640714-45-0
• Molecular Formula: C₁₇H₁₉NO₄S
• Molecular Weight: 333.40206
• Mol File: 640714-45-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-mesityl-2,3-dihydro-1,4-benzodioxine-6-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-mesityl-2,3-dihydro-1,4-benzodioxine-6-sulfonamide(640714-45-0)
• EPA Substance Registry System: N-mesityl-2,3-dihydro-1,4-benzodioxine-6-sulfonamide(640714-45-0)

Safety Data

• Hazardous Substances Data: 640714-45-0(Hazardous Substances Data)

Upstream product

• 63758-12-3 6-chlorosulfonyl-1,4-benzodioxane 
• 88-05-1 2,4,6-trimethylaniline 

Relevant articles and documents

Identification of arylsulfonamides as ExoU inhibitors

ExoU is a potent virulence factor of Pseudomonas aeruginosa and is considered a potential therapeutic target. In order to discover novel ExoU inhibitors, we screened an in-house chemical library utilizing a yeast-based screening system. Some sulfonamides displayed significant activity without nonspecific cytotoxicity. We describe a series of sulfonamides as novel ExoU inhibitors, along with a brief structure-activity relationship.

Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)

The exploration of a diarylsulfonamide series of free fatty acid receptor 4 (FFA4/GPR120) agonists is described. This work led to the identification of selective FFA4 agonist 8 (GSK137647A) and selective FFA4 antagonist 39. The in vitro profile of compounds 8 and 39 is presented herein.