640720-46-3Relevant academic research and scientific papers
Synthesis of 9-methyl-1H-[1,4]thiazino[3,2-g]quinoline-2,5,10(3H)-trione, the B,C,D ring core of the shermilamine alkaloids
Townsend, Norman O.,Jackson, Yvette A.
, p. 3557 - 3563 (2003)
The synthesis of 9-methyl-1H-[1,4]thiazino[3,2-g]quinoline-2,5,10(3H)-trione(4), from N-(4-bromo-2,5-dimethoxyphenyl)acetamide was discussed. Oxidative cyclisation of 2,2′-disulfanediylbis[N-2,5-dimethoxyphenyl)acetamide] to 5,8-dimethoxy-2H-1,4-benzothiazin-3(4H)-one(7b) was reported. It was found that the reaction proceeded through the disulfide and iodine acted as an oxidizing agent, enabling the cyclization.
