640722-85-6

Basic information

• Product Name: (R)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-tritylsulfanyl-propionic acid allyl ester
• CAS NO: 640722-85-6
• Molecular Weight: 696.867
• Mol File: 640722-85-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-tritylsulfanyl-propionic acid allyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-tritylsulfanyl-propionic acid allyl ester(640722-85-6)
• EPA Substance Registry System: (R)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-tritylsulfanyl-propionic acid allyl ester(640722-85-6)

Safety Data

• Hazardous Substances Data: 640722-85-6(Hazardous Substances Data)

Upstream product

• 640722-84-5 allyl 2(R)-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tritylthio)propanoate 
• 35661-38-2 N-(9-fluorenylmethoxycarbonyl)-D-alanine 
• 1026823-61-9 S-triphenylmethyl-cysteine allyl ester 

Downstream Products

• 176666-84-5 dendroamide A 

Relevant articles and documents

Total Synthesis of Dendroamide A: Oxazole and Thiazole Construction Using an Oxodiphosphonium Salt

The total synthesis of dendroamide A (1), a multidrug-resistance reversing bistratamide-type peptide-derived macrocycle, has been accomplished in 19% yield. Fmoc-protected amino acids were condensed into appropriately protected dipeptides which were treated with bis-(triphenyl)oxodiphosphonium trifluoromethanesulfonate to afford oxazoles and thiazolines (oxidized to thiazoles) with high chemo- and stereoselectivity. The convergent condensation of three heterocyclic amino acids followed by macrocyclization afforded the natural product.