640734-50-5Relevant academic research and scientific papers
A total synthesis of the antibiotic DB-2073
Covarrubias-Zuniga, Adrian,Avila-Zarraga, Jose G.,Arias Salas, David
, p. 3173 - 3181 (2007/10/03)
A convergent aromatic annulation strategy based on the Michael addition of the dimethyl-1,3-acetonedicarboxylate 1 anion to 2-hexynal 2, followed by a regiocontrolled Dieckmann-type cyclization, has been applied to a total synthesis of the antibiotic, DB-2073 I. This tandem annulation reaction generates the fully substituted aromatic intermediate 3, which was transformed by a five-step sequence to I.
