640766-56-9Relevant academic research and scientific papers
Distance-Dependent Attractive and Repulsive Interactions of Bulky Alkyl Groups
Hwang, Jungwun,Li, Ping,Smith, Mark D.,Shimizu, Ken D.
, p. 8086 - 8089 (2016)
The stabilizing and destabilizing effects of alkyl groups on an aromatic stacking interaction were experimentally measured in solution. The size (Me, Et, iPr, and tBu) and position (meta and para) of the alkyl groups were varied in a molecular balance mod
Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide
Shahripour, Aurash B,Plummer, Mark S,Lunney, Elizabeth A,Sawyer, Tomi K,Stankovic, Charles J,Connolly, Michael K,Rubin, John R,Walker, Nigel P.C,Brady, Kenneth D,Allen, Hamish J,Talanian, Robert V,Wong, Winnie W,Humblet, Christine
, p. 2779 - 2782 (2007/10/03)
A series of compounds was designed and prepared as inhibitors of interleukin-1β converting enzyme (ICE), also known as caspase-1. These inhibitors, which employ a diphenyl ether sulfonamide, were designed to improve potency by forming favorable interactions between the diphenyl ether rings and the prime side hydrophobic region. An X-ray crystal structure of a representative member of the diphenyl ether sulfonamide series bound to the active site of caspase-1 was obtained.
