640769-70-6

Basic information

• Product Name: 3-PYRIMIDIN-5-YLBENZALDEHYDE
• Synonyms: AKOS BAR-0649;3-(5-PYRIMIDINYL)BENZALDEHYDE;3-PYRIMIDIN-5-YLBENZALDEHYDE;3-(2-(4-Methylpiperazin-1-yl)pyrimidin-5-yl)benzaldehyde;3-(2-(Dimethylamino)pyrimidin-5-yl)benzaldehyde;3-(2-(Piperidin-1-yl)pyrimidin-5-yl)benzaldehyde;3-(2-(Pyrrolidin-1-yl)pyrimidin-5-yl)benzaldehyde;3-(2-Chloro-6-(dimethylamino)pyrimidin-5-yl)benzaldehyde
• CAS NO: 640769-70-6
• Molecular Formula: C11H8N2O
• Molecular Weight: 184.19
• Mol File: 640769-70-6.mol

Chemical Properties

• Boiling Point: 374.7 °C at 760 mmHg
• Flash Point: 183.8 °C
• Appearance: /
• Density: 1.205 g/cm³
• Vapor Pressure: 8.18E-06mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1?+-.0.10(Predicted)
• CAS DataBase Reference: 3-PYRIMIDIN-5-YLBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PYRIMIDIN-5-YLBENZALDEHYDE(640769-70-6)
• EPA Substance Registry System: 3-PYRIMIDIN-5-YLBENZALDEHYDE(640769-70-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 640769-70-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Pyrimidin-5-ylbenzaldehyde is used as an intermediate in the synthesis of pyrimidine derivatives, which are integral to the development of pharmaceutical drugs. Its presence in the synthesis process is crucial for the creation of drugs that target a variety of health conditions, thereby contributing to advancements in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Pyrimidin-5-ylbenzaldehyde is also utilized as a starting material for the production of various biologically active compounds. These compounds are essential in developing agrochemicals that enhance crop protection and contribute to sustainable agricultural practices.
Used in Organic Synthesis:
3-Pyrimidin-5-ylbenzaldehyde is employed as a key component in organic synthesis, where it serves as a precursor to a multitude of chemical reactions. Its versatility allows for the creation of a wide range of compounds with applications spanning across various industries, highlighting its importance in the field of chemistry.

InChI:InChI=1/C11H8N2O/c14-7-9-2-1-3-10(4-9)11-5-12-8-13-6-11/h1-8H

Upstream product

• 852180-75-7 (3-(pyrimidin-5-yl)phenyl)methanol 

Downstream Products

• 1428968-38-0 1-(1H-indol-3-yl)-2-((3-methoxyphenyl)amino)-2-(3-(pyrimidin-5-yl)phenyl)ethanone 

Relevant articles and documents

A “universal” catalyst for aerobic oxidations to synthesize (hetero)aromatic aldehydes, ketones, esters, acids, nitriles, and amides

Functionalized (hetero)aromatic compounds are indispensable chemicals widely used in basic and applied sciences. Among these, especially aromatic aldehydes, ketones, carboxylic acids, esters, nitriles, and amides represent valuable fine and bulk chemicals, which are used in chemical, pharmaceutical, agrochemical, and material industries. For their synthesis, catalytic aerobic oxidation of alcohols constitutes a green, sustainable, and cost-effective process, which should ideally make use of active and selective 3D metals. Here, we report the preparation of graphitic layers encapsulated in Co-nanoparticles by pyrolysis of cobalt-piperazine-tartaric acid complex on carbon as a most general oxidation catalyst. This unique material allows for the synthesis of simple, functionalized, and structurally diverse (hetero)aromatic aldehydes, ketones, carboxylic acids, esters, nitriles, and amides from alcohols in excellent yields in the presence of air.

PIPERIDINES USEFUL FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS

The invention relates to compounds which are substituted chiral or achiral derivatives of 3- or 4- aminopiperidine of the general formula (I). The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of general formula I and especially their use as inhibitors of β-secretases.

SUBSTITUTED 3- AND 4- AMINOMETHYLPIPERIDINES FOR USE AS BETA-SECRETASE IN THE TREATMENT OF ALZHEIMER’S DISEASE

The invention relates to novel compounds, which are substituted chiral or achiral derivatives of 3- or 4- aminomethylpiperidine of the general formula (I). The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of general formula (I) and especially their use as inhibitors of beta-secretases for the treatment of Alzheimer’s disease.