640769-71-7

Basic information

• Product Name: 2-(Pyrimidin-5-yl)benzaldehyde
• Synonyms: AKOS BAR-0660;2-(5-PYRIMIDINYL)BENZALDEHYDE;2-PYRIMIDIN-5-YLBENZALDEHYDE
• CAS NO: 640769-71-7
• Molecular Formula: C₁₁H₈N₂O
• Molecular Weight: 184.19
• Product Categories: Heterocyclic Compound;Benzaldehyde
• Mol File: 640769-71-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 375.8 °C at 760 mmHg
• Flash Point: 184.5 °C
• Appearance: /
• Density: 1.205 g/cm³
• Vapor Pressure: 7.56E-06mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-(Pyrimidin-5-yl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Pyrimidin-5-yl)benzaldehyde(640769-71-7)
• EPA Substance Registry System: 2-(Pyrimidin-5-yl)benzaldehyde(640769-71-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-39
• Hazardous Substances Data: 640769-71-7(Hazardous Substances Data)

Usage

General Description

2-(Pyrimidin-5-yl)benzaldehyde is a chemical compound with the molecular formula C12H8N2O. It consists of a benzene ring with a pyrimidine group attached at the 2-position and an aldehyde group attached at the 5-position. 2-(Pyrimidin-5-yl)benzaldehyde is commonly used in organic synthesis and as a reagent in various chemical reactions. It acts as a building block in the production of pharmaceuticals, agrochemicals, and other organic compounds. Its unique structure and reactivity make it a valuable tool for the creation of new molecules with potential biological or industrial applications.

InChI:InChI=1/C11H8N2O/c14-7-9-3-1-2-4-11(9)10-5-12-8-13-6-10/h1-8H

Upstream product

• 4595-59-9 5-bromopyrimidine 
• 1256169-22-8 bis[2-(diethoxymethyl)phenyl]zinc 
• 40138-16-7 2-formylbenzene boronic acid 
• 497-19-8 sodium carbonate 

Downstream Products

• 1033806-01-7 2,2,2-trifluoro-1-(2-pyrimidin-5-yl-phenyl)ethanol 

Relevant articles and documents

Palladium-Catalyzed meta-C-H Olefination of Arene-Tethered Diols Directed by Well-Designed Pyrimidine-Based Group

The palladium-catalyzed meta-olefination of arene-tethered diols attached to a well-designed pyrimidine moiety is presented. Applications of the protocol are illustrated by the synthesis of various diol-based natural products, such as coumarins, phenylpropanoids, stilbenes, and chalcones. Advantages of this method are demonstrated through the easy removal of the template and a gram-scale olefination reaction. Finally, experimental verification, including 1H NMR, ESI-MS and IR, and DFT studies are undertaken to elucidate the mechanistic complexity.

Based on 4 - phenyl -6 - (2, 2, 2 - trifluoro -1 - phenyl ethoxy) pyrimidine compound and its application method

The present invention relates to compounds based on 4-phenyl-6-(2,2,2-trifluoro-1-phenyl ethoxy) pyrimidine and an application method thereof, particularly discloses compounds of formula I and compositions comprising the compounds, and the application method thereof in treatment, prevention and / or management of diseases or disorders.

METHODS OF AFFECTING GASTROINTESTINAL TRANSIT AND GASTRIC EMPTYING, AND COMPOUNDS USEFUL THEREIN

Methods and compounds are disclosed for affecting gastrointestinal motility and gastric emptying, which comprise inhibiting tryptophan hydroxylase (TPH) in patients in need thereof.