Cas 640772-88-9,2,2-difluoro-N-{[(5S)-3-(3-fluoro-4-piperazin-1-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide

640772-88-9

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Basic information

Product Name: 2,2-difluoro-N-{[(5S)-3-(3-fluoro-4-piperazin-1-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide
Synonyms: 2,2-difluoro-N-{[(5S)-3-(3-fluoro-4-piperazin-1-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide
CAS NO:640772-88-9
Molecular Formula:
Molecular Weight: 372.347
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 2,2-difluoro-N-{[(5S)-3-(3-fluoro-4-piperazin-1-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide(CAS DataBase Reference)
NIST Chemistry Reference: 2,2-difluoro-N-{[(5S)-3-(3-fluoro-4-piperazin-1-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide(640772-88-9)
EPA Substance Registry System: 2,2-difluoro-N-{[(5S)-3-(3-fluoro-4-piperazin-1-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide(640772-88-9)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 640772-88-9(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 640772-88-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,4,0,7,7 and 2 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 640772-88:
(8*6)+(7*4)+(6*0)+(5*7)+(4*7)+(3*2)+(2*8)+(1*8)=169
169 % 10 = 9
So 640772-88-9 is a valid CAS Registry Number.

640772-88-9Upstream product

1140172-15-1 C₂₁H₂₇F₃N₄O₅

640772-88-9Downstream Products

640772-88-9Relevant academic research and scientific papers

Synthesis and biological activity of novel oxazolidinones

Das, Biswajit,Rajarao,Rudra, Sonali,Yadav, Ajay,Ray, Abhijit,Pandya, Manisha,Rattan, Ashok,Mehta, Anita

supporting information; experimental part, p. 6424 - 6428 (2010/05/02)

A number of 5-substituted derivatives of Ranbezolid, a novel oxazolidinone were synthesized. Antibacterial activity of the compounds against a number of sensitive and resistant bacteria showed promising results.

Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents

Takhi, Mohamed,Singh, Gurpreet,Murugan,Thaplyyal, Nirvesh,Maitra, Soma,Bhaskarreddy,Amarnath,Mallik, Arundhuti,Harisudan,Trivedi, Ravi Kumar,Sreenivas,Selvakumar,Iqbal, Javed

scheme or table, p. 5150 - 5155 (2009/05/26)

Novel oxazolidinone antibacterials bearing a variety of 3-indolylglyoxamide substituents have been explored in an effort to improve the spectrum and potency of this class of agents. A subclass of this series was also made with the diversity at C-5 terminus. These derivatives have been screened against a panel of clinically relevant Gram-positive pathogens and fastidious Gram-negative organisms. Several analogs in this series were identified with in vitro activity superior to linezolid (MIC = 0.25-2 μg/mL). Compounds 10a, 10c, 10e and 10f displayed activity against linezolid resistant Gram-positive organisms (MIC = 2-4 μg/mL). Selected oxazolidinones were evaluated for in vivo efficacy against a mouse systemic infection model.

NOVEL OXAZOLIDINONE DERIVATIVES

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Page/Page column 31-32, (2010/11/29)

The present invention relates to novel compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodr

GLYCOLOYL-SUBSTITUTED OXAZOLIDINONE-DERIVATIVES AS ANTIBACTERIAL AGENTS

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Page/Page column 9-10, (2010/11/30)

The present invention describes difluororthioacetamide oxazolidinones_of formula I with a glycoloylpiperazine substituent as novel antibacterial agents, and antimicrobial combination therapies for combatting infective diseases caused by gram-positive and

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