64088-81-9Relevant academic research and scientific papers
An expedient large-scale preparation of a dibenz[b,e]oxepinone derivative
Lee, Thomas B.K.,Tebben, Andrew J.,Weiberth, Franz J.,Wong, George S.K.
, p. 747 - 751 (2007/10/03)
A convenient, large-scale synthesis of a dibenz[b,e]oxepinone derivative is described. The dibenz[-b,e]oxepinone ring system is constructed using an iron chloride catalyzed intramolecular Friedel-Crafts cyclization of an appropriate phenoxymethylbenzoic acid chloride in toluene, reagents and conditions that are economically and environmentally compatible with large- scale preparation.
Dibenzoxepinone hydroxylamines and hydroxamic acids: Dual inhibitors of cyclooxygenase and 5-lipoxygenase with potent topical antiinflammatory activity
Hamer, R. Richard L.,Tegeler, John J.,Kurtz, Ellen S.,Allen, Richard C.,Bailey, Steven C.,Elliott, Mary Ellen,Hellyer, Luther,Helsley, Grover C.,Przekop, Penelope,Freed, Brian S.,White, John,Martin, Lawrence L.
, p. 246 - 252 (2007/10/03)
Hydroxylamine and hydroxamic acid derivatives of a known nonsteroidal antiinflammatory dibenzoxepine series display both cyclooxygenase (CO) and 5- lipoxygenase (5-LO) inhibitory properties. Many of these new dual CO/5-LO inhibitors also exhibit potent topical antiinflammatory activity in the arachidonic acid-induced murine ear edema model. On the basis of their promising profile of in vitro and in vivo activities, hydroxamic acids 24h, 3-(6,11-dihydro-11-oxodibenz[b,e]oxepin-2-yl)-N-hydroxy-N-methylpropanamide (HP 977), and 25, 3-(6,11-dihydrodibenz[b,e]oxepin-2-yl)-N-hydroxy-N- methylpropanamide (P10294), were selected as developmental candidates for the topical treatment of inflammatory skin disorders.
Method of treating dermal inflammations
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, (2008/06/13)
A method of treating dermal inflammation by topically administering to a patient an effective amount of a 6,11-dihydrodibenz[b,e]oxepinalkanoic acid, physiologically tolerable salt thereof, derivative thereof, or diacid precursor thereof is described.
Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 3. ω (6,11 Dihydro 11 oxodibenz[b,e]oxepin 2 yl)alkanoic acids
Aultz,McFadden,Lassman
, p. 1499 - 1501 (2007/10/13)
ω-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)butyric,-hexanoic, and -octanoic acids were evaluated in the carrageenan paw edema assay. The most active compound, the butyric acid analogue, was 1.80 times more potent than the hexanoic compound, 1.15 times m
