64096-98-6Relevant academic research and scientific papers
Process for preparing ortho-(alkylthio)phenols
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, (2008/06/13)
The process of the invention involves reacting a phenol with a dialkyl disulfide in the presence of a zirconium phenoxide catalyst to prepare the corresponding ortho-(alkylthio)phenol.
2-(Aminomethyl)phenols, a new class of saluretic agents. I. Effect of nuclear substitution
Stokker,Deana,deSolms,Schultz,Smith,Cragoe Jr.,Baer,Ludden,Russo,Scriabine,Sweet,Watson
, p. 1414 - 1427 (2007/10/02)
A series of 2-(aminomethyl)phenols was synthesized and tested in rats and dogs for saluretic and diuretic activity. A number of these compounds exhibit a high order of activity on iv or po administration. The most active compounds belong to a subseries of 4-alkyl-6-halo derivatives of which 2,2(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenyl, is the most active. Compound 2 also possesses significant antihypertensive activity, an adjunctive pharmacological parameter which distinguishes 2 from the other compounds prepared in this series. In addition, 2 displays both topical saluretic and antiinflammatory activities.
